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자료유형
학술저널
저자정보
이강호 (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) 류동연 (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) 김호현 (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea.) Park Sung Jin (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) 이상봉 (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) Park Chan Ik (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) Kim Gil Hwan (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) 김선현 (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea) 이나현 (Department of Trauma and Surgical Critical Care Pusan National University Hospital Busan Korea)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제38권 제1호
발행연도
2023.2
수록면
95 - 103 (9page)
DOI
10.4266/acc.2022.01046

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Background In patients with severe trauma, the diagnosis of acute kidney injury (AKI) is important because it is a predictive factor for poor prognosis and can affect patient care. The diagnosis and staging of AKI are based on change in serum creatinine (SCr) levels from baseline. However, baseline creatinine levels in patients with traumatic injuries are often unknown, making the diagnosis of AKI in trauma patients difficult. This study aimed to enhance the accuracy of AKI diagnosis in trauma patients by presenting an appropriate reference creatinine estimate (RCE). Methods We reviewed adult patients with severe trauma requiring intensive care unit admission between 2015 and 2019 (n=3,228) at a single regional trauma center in South Korea. AKI was diagnosed based on the current guideline published by the Kidney Disease: Improving Global Outcomes organization. AKI was determined using the following RCEs: estimated SCr75-modification of diet in renal disease (MDRD), trauma MDRD (TMDRD), admission creatinine level, and first-day creatinine nadir. We assessed inclusivity, prognostic ability, and incrementality using the different RCEs. Results The incidence of AKI varied from 15% to 46% according to the RCE used. The receiver operating characteristic curve of TMDRD used to predict mortality and the need for renal replacement therapy (RRT) had the highest value and was statistically significant (0.797, P<0.001; 0.890, P=0.002, respectively). In addition, the use of TMDRD resulted in a mortality prognostic ability and the need for RRT was incremental with AKI stage. Conclusions In this study, TMDRD was feasible as a RCE, resulting in optimal post-traumatic AKI diagnosis and prognosis.

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