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논문 기본 정보

자료유형
학술저널
저자정보
권기진 (휴네이처) 박서윤 (디에스메카㈜) 이평호 ((주)신영아이템산업) 이인상 ((주)디바인 연구소) 신미정 (한국폴리텍대학) 양지웅 (부산대학교(밀양캠퍼스)) 이은숙 (부산대학교) 박대겸 (부산대학교)
저널정보
아태인문사회융합기술교류학회 아시아태평양융합연구교류논문지 아시아태평양융합연구교류논문지 제9권 제1호
발행연도
2023.1
수록면
191 - 203 (13page)
DOI
http://dx.doi.org/10.47116/apjcri.2023.01.16

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From the viewpoint that hydrogen water can restore damaged functions by removing active oxygen that is harmful to the human body, the effect on skin wrinkles was investigated and analyzed through additional research.This study aims to examine into the applicability of hydrogen water to the human body, the safety of drinking Distilled Water (DW), Hydrogen Water (HW), Electrolyzed Hydrogen Water( EHW), Oxinium Ion Water (OIW), and the improvement effect on wrinkles due to photoaging. For the research purpose, a preclinical study was conducted using hairless mice, and the pH and dissolved hydrogen amount were measured at the same time each day, and 200 ml of the hydrogen water was provided to hairless mice for four weeks. First, the hairless mice were divided into two groups: the group irradiated with UV and the control group not irradiated with UV. The group irradiated with UV was subdivided into four groups: physiological saline group, HW group, EHW group, and OIW group. The physiological saline was the vehicle application group (n=5), and the other three groups were treated by oral administration and skin application(group n=5). Oral administration was performed by 6 ccs once a day, and UV treatment was performed by fixing the mice on a tray three times a week for four weeks to measure hydrogen water's stability and wrinkle-improvement effect. By examining the safety of drinking hydrogen water through mortality, weight change, blood biochemical change and inflammation, immune cell comparison, morphological change of internal organs, organ weight change, and histological inspection of the hairless mice, the effect of hydrogen water on the living body was confirmed. Furthermore, the pH change was within the scope of alkalescent, pH 6.52-8.9, and met the standard of drinking hydrogen water, and the contained dissolved hydrogen was over the acceptable standard, 200 ppb=0.2 ppm. As a result of observation, the experimental group administered hydrogen water did not show any death or symptoms of abnormality in behavior and appearance. Also, there was no significant change in the weight and organ weight of the group. No pathological abnormalities were observed in serum and blood cell analysis and liver and kidney tissue analysis. Skin wrinkle formation in the Vehicle (UV) group increased by 78.26% compared to that of the control(no) group, and in the HW group, it decreased by 30.43% compared to that of the Vehicle (UV) group. Skin thickness increased by 30.83% in the Vehicle(UV) group compared to the control(no) group, and in the HW group, it decreased by 25.33% compared to the Vehicle(UV) group. And the thickness of the epidermis of the Vehicle(UV) group increased by 62.13% compared to the control(no) group. The thickness of keratin increased by 57.63% in the Vehicle(UV) group compared to the control(no) group, and in the HW group, it decreased by 40.98% compared to the Vehicle(UV) group. Erythema decreased by 22.82% in the HW group compared to that of the Vehicle(UV) group, the amount of moisture reduction was 15.77% in the HW group compared to that of the Vehicle(UV) group, and the water content increased by 16.53% in the HW group compared to that of the Vehicle(UV) group. The findings of this study show that UV-skin impulse and hydrogen water administration into the body present different results depending on the amount of dissolved hydrogen, skin thickness, epidermis thickness, and keratin thickness. Moreover, its results are significant as it contributes to improving wrinkles and preventing skin aging. Also, it is expected to be used for skin health and beauty to help people's lives.
#Haieless Mice #Hydrogen Water #Photoaging #Skin Wrinkle #UV-Irradiation

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