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자료유형
학술저널
저자정보
안효정 (서울대학교병원) Lee So-Ryoung (Seoul National University Hospital) 최의근 (Department of Internal Medicine Seoul National University Hospital Seoul Korea.Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.) 이승우 (Department of Medical Statistics College of Medicine The Catholic University of Korea Seoul Korea.) 한경도 (숭실대학교) 권순 (Department of Internal Medicine Seoul National University Hospital Seoul Korea.) 오세일 (Department of Internal Medicine Seoul National University Hospital Seoul Korea.Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.) Gregory Y. H. Lip (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Chest)
저널정보
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제12권 제1호
발행연도
2023.1
수록면
73 - 86 (14page)
DOI
10.12997/jla.2023.12.1.73

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Objective Higher levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) are associated with a lower risk of atrial fibrillation (AF). Statin use might exert confounding effects on the paradoxical associations; however, the relationships that distinguish statin users from non-users have not been thoroughly evaluated. Methods From the Korean National Health Insurance Database, we included 9,778,014 adults who underwent a health examination in 2009. The levels of TC and LDL-C at the health examination were categorized into quartile values of the total study population. We grouped the study population into statin users and non-users and investigated the associations between TC, LDL-C, and the risk of incident AF. Results Of the total population, 867,336 (8.9%) were taking statins. During a mean follow-up of 8.2 years, inverse associations of TC – AF and LDL-C – AF were observed; higher levels of TC and LDL-C were associated with the lower risk of AF in the total population. Overall, statin users showed higher AF incidence rate than non-users, but the inverse associations of TC – AF and LDL-C – AF were consistently observed irrespective of statin usage; adjusted hazard ratio with 95% confidence interval was 0.81 (0.79–0.84) for statin users and 0.81 (0.80–0.83) for non-users in the highest TC quartile, and 0.84 (0.82–0.87) for statin users and 0.85 (0.84–0.86) for non-users in the highest LDL-C quartile (all p<0.001). Conclusion The paradoxical relationship between lipid levels (TC and LDL-C) and the risk of AF remains consistent in both statin users and non-users.

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