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자료유형
학술저널
저자정보
Ryu Jae-Chan (Department of Neurology Asan Medical Center University of Ulsan College of Medicine) Lee Dongwhane (Department of Neurology Uijeongbu Eulji Medical Center Eulji University School of Medicine) Kwon Sun U. (Department of Neurology Asan Medical Center University of Ulsan College of Medicine Seoul Korea) Chang Jun Young (Department of Neurology Asan Medical Center University of Ulsan College of Medicine Seoul Korea)
저널정보
대한신경집중치료학회 Journal of Neurocritical Care Journal of Neurocritical Care Vol.16 No.1
발행연도
2023.6
수록면
28 - 33 (6page)
DOI
10.18700/jnc.230011

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Background: Delayed post-ischemic leukoencephalopathy (DPIL) is a rare complication after mechanical thrombectomy, with no well-established clinical characteristics and patho-mechanism. We explored the characteristics and possible mechanisms in three patients with DPIL. Case Report: Based on the clinical manifestations and laboratory findings including magnetic-resonance imaging, magnetic resonance spectroscopy, electroencephalography, and lumbar puncture, DPIL was diagnosed in three patients. We administered antiplatelet agents and conservative treatment. Cardioembolism, successful recanalization using a balloon guiding catheter, and fluctuating or gradually worsening neurological symptoms in delayed phase between 13 and 70 days were common features of DPIL. Diffusion-weighted imaging and fluid-attenuated inversion recovery showed high-signal intensity in the affected subcortical white matter. Laboratory findings provided no evidence of an epileptic disorder, inflammatory demyelination, or tumorous conditions. Conclusion: This report shows the characteristics and neuroradiologic images of DPIL. Among the various hypotheses, regional hypoxic-ischemic leukoencephalopathy and delayed reperfusion injury might be the patho-mechanism underlying DPIL.

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