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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.12 No.2
- 발행연도
- 2022.5
- 수록면
- 97 - 124 (28page)
- DOI
- https://doi.org/10.1007/s13534-022-00220-4
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초록· 키워드
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Functional blood imaging can reflect tissue metabolism and organ viability, which is important for life science and biomedicalstudies. However, conventional imaging modalities either cannot provide sufficient contrast or cannot support simultaneousmulti-functional imaging for hemodynamics. Photoacoustic imaging, as a hybrid imaging modality, can provide sufficientoptical contrast and high spatial resolution, making it a powerful tool for in vivo vascular imaging. By using the opticalacousticconfocal alignment, photoacoustic imaging can even provide subcellular insight, referred as optical-resolutionphotoacoustic microscopy (OR-PAM). Based on a multi-wavelength laser source and developed the calculation methods,OR-PAM can provide multi-functional hemodynamic microscopic imaging of the total hemoglobin concentration (CHb),oxygen saturation (sO2), blood flow (BF), partial oxygen pressure (pO2), oxygen extraction fraction, and metabolic rate ofoxygen (MRO2). This concise review aims to systematically introduce the principles and methods to acquire various functionalparameters for hemodynamics by photoacoustic microscopy in recent studies, with characteristics and advantagescomparison, typical biomedical applications introduction, and future outlook discussion.
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