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논문 기본 정보

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학술저널
저자정보
Steven L Ciciora (Division of Gastroenterology Hepatology and Nutrition Nationwide Children’s Hospital Columbus OH USA) Kandamurugu Manickam (Department of Pediatrics The Ohio State University College of Medicine Columbus OH USA) Miguel Saps (Division of Pediatric Gastroenterology Hepatology and Nutrition University of Miami Miller School of Medicine Miami FL USA)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.29 No.1
발행연도
2023.1
수록면
94 - 101 (8page)
DOI
10.5056/jnm22055

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Background/AimsDisorders of brain-gut interaction (DGBIs) are present in adults and children around the world. Down syndrome (DS) is the most common chromosomal condition in humans. While DS has associations with many organic medical conditions, the frequency of DGBIs in children and adolescents with DS has not previously been studied. We assess the rate of DGBIs in children and adolescents 4-18 years of age with DS in the United States using the Rome IV criteria by caregiver report.MethodsThis is a cross-sectional national survey study in which caregivers (n = 114) of children with DS completed an online survey about their child’s gastrointestinal symptoms and quality of life (QoL).ResultsUsing the Rome IV parent-report diagnostic questionnaire, 51.8% of children met symptom-based criteria for at least 1 DGBI. Functional constipation (36.0%) and irritable bowel syndrome (14.9%) were the most common disorders identified. QoL was lower in children with at least 1 disorder as compared to children who did not meet criteria for any disorders (mean QoL = 62.3 vs mean QoL = 72.9, P < 0.001). Almost all children with DS and concomitant autism (87.5%) had at least 1 DGBI.ConclusionsDGBIs are common in children with DS and are associated with diminished QoL.

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