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논문 기본 정보

자료유형
학술저널
저자정보
Hassan Amini (Stem Cell Research Center Tabriz University of Medical Sciences) Atieh Rezaei Namjoo (Stem Cell Research Center Tabriz University of Medical Sciences) Maryam Taghavi Narmi (Drug Applied Research Center) Narges Mardi (Student Research Committee Tabriz University of Medical Sciences) Samaneh Narimani (Stem Cell Research Center Tabriz University of Medical Sciences) Ozra Naturi (Department of Organic and Biochemistry Faculty of Chemistry University of Tabriz) Nafseh Didar Khosrowshahi (Stem Cell and Tissue Engineering Research Laboratory Sahand University of Technology) Reza Rahbarghazi (Tabriz University of Medical Sciences) Reza Rahbarghazi (Tabriz University of Medical Sciences) Solmaz Saghebasl (Stem Cell Research Center Tabriz University of Medical Sciences) Shahriar Hashemzadeh (Department of General and Vascular Surgery Tabriz University of Medical Sciences) Mohammad Nouri (Stem Cell Research Center Tabriz University of Medical Sciences)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
2,316 - 2,339 (24page)
DOI
https://doi.org/10.1186/s40824-023-00433-3

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BackgroundIn recent years, cardiovascular disease in particular myocardial infarction (MI) has become the predominant cause of human disability and mortality in the clinical setting. The restricted capacity of adult cardiomyocytes to proliferate and restore the function of infarcted sites is a challenging issue after the occurrence of MI. The application of stem cells and byproducts such as exosomes (Exos) has paved the way for the alleviation of cardiac tissue injury along with conventional medications in clinics. However, the short lifespan and activation of alloreactive immune cells in response to Exos and stem cells are the main issues in patients with MI. Therefore, there is an urgent demand to develop therapeutic approaches with minimum invasion for the restoration of cardiac function. Main bodyHere, we focused on recent data associated with the application of Exo-loaded hydrogels in ischemic cardiac tissue. Whether and how the advances in tissue engineering modalities have increased the efficiency of whole-based and byproducts (Exos) therapies under ischemic conditions. The integration of nanotechnology and nanobiology for designing novel smart biomaterials with therapeutic outcomes was highlighted. ConclusionHydrogels can provide suitable platforms for the transfer of Exos, small molecules, drugs, and other bioactive factors for direct injection into the damaged myocardium. Future studies should focus on the improvement of physicochemical properties of Exo-bearing hydrogel to translate for the standard treatment options.

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