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논문 기본 정보

자료유형
학술저널
저자정보
Zhiyong Chen (State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Shanghai Stomatological Hospital & School of Stomatology Fudan University) Yu Chen (State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Shanghai Stomatological Hospital & School of Stomatology Fudan University) Yang Wang (State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Shanghai Stomatological Hospital & School of Stomatology Fudan University) JiaJia Deng (Department of Orthodontics Shanghai Stomatological Hospital & School of Stomatology Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Fudan University) Xin Wang (State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Shanghai Stomatological Hospital & School of Stomatology Fudan University) Qingqing Wang (Department of Orthopaedic Surgery Sir Run Run Shaw Hospital Medical College of Zhejiang University) Yuehua Liu (Department of Orthodontics Shanghai Stomatological Hospital & School of Stomatology Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases Fudan University) Jiandong Ding (State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Shanghai Stomatological Hospital & School of Stomatology Fudan University) Lin Yu (State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Shanghai Stomatological Hospital & School of Stomatology Fudan University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,588 - 1,608 (21page)
DOI
https://doi.org/10.1186/s40824-023-00407-5

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Background Good osseointegration is the key to the long-term stability of bone implants. Thermoplastic polyethere therketone (PEEK) has been widely used in orthopedics; however, its inherent biological inertia causes fbrous tissue to wrap its surface, which leads to poor osseointegration and thus greatly limits its clinical applications. Methods Herein, we developed a facile yet efective surface modifcation strategy. A commonly used sulfonation coupled with “cold pressing” treatment in the presence of porogenic agent formed a three-dimensional hierarchical porous structure on PEEK surface. Subsequently, the efects of porous surface on the in vitro adhesion, proliferation and diferentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs) were evaluated. Finally, the osteoin duction and osseointegration of surface-porous PEEK implant were examined in the rat distal femoral defect model. Results In vitro results showed that the surface modifcation did not signifcantly afect the mechanical performance and cytocompatibility of PEEK substance, and the porous structure on the modifed PEEK substrate provided space for cellular ingrowth and enhanced osteogenic diferentiation and mineralization of BMSCs. In vivo tests demonstrated that the surface-porous PEEK implant could efectively promote new bone formation and had higher bone-implant contact rate, thereby achieving good bone integration with the surrounding host bone. In addition, this modifcation technique was also successfully demonstrated on a medical PEEK interbody fusion cage. Conclusion The present study indicates that topological morphology plays a pivotal role in determining implant osseointegration and this facile and efective modifcation strategy developed by us is expected to achieve practical applications quickly.
#PEEK #Surface modifcation #Biomaterials #Cold pressing #Hierarchical porous structure #Osseointegration

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