지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.4
- 수록면
- 253 - 259 (7page)
- DOI
- https://doi.org/10.3803/EnM.2022.1607
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초록· 키워드
오류제보하기
Background: The severity of coronavirus disease 2019 (COVID-19) among patients with long-term glucocorticoid treatment(LTGT) has not been established. We aimed to evaluate the association between LTGT and COVID-19 prognosis.
Methods: A Korean nationwide cohort database of COVID-19 patients between January 2019 and September 2021 was used. LTGTwas defined as exposure to at least 150 mg of prednisolone (≥5 mg/day and ≥30 days) or equivalent glucocorticoids 180 days before COVID-19 infection. The outcome measurements were mortality, hospitalization, intensive care unit (ICU) admission, length ofstay, and mechanical ventilation.
Results: Among confirmed patients with COVID-19, the LTGT group (n=12,794) was older and had a higher proportion of comorbidities than the control (n=359,013). The LTGT group showed higher in-hospital, 30-day, and 90-day mortality rates than the control (14.0% vs. 2.3%, 5.9% vs. 1.1%, and 9.9% vs. 1.8%, respectively; all P<0.001). Except for the hospitalization rate, the length ofstay, ICU admission, and mechanical ventilation proportions were significantly higher in the LTGT group than in the control (allP<0.001). Overall mortality was higher in the LTGT group than in the control group, and the significance remained in the fully adjusted model (odds ratio [OR], 5.75; 95% confidence interval [CI], 5.31 to 6.23) (adjusted OR, 1.82; 95% CI, 1.67 to 2.00). TheLTGT group showed a higher mortality rate than the control within the same comorbidity score category.
Conclusion: Long-term exposure to glucocorticoids increased the mortality and severity of COVID-19. Prevention and early proactive measures are inevitable in the high-risk LTGT group with many comorbidities.
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