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논문 기본 정보

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학술저널
저자정보
Moon Yeji (Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Jung Jae Ho (Department of Ophthalmology Seoul National University Hospital Seoul National University College of Medicine Seoul Korea.) Shin Hyun Jin (Department of Ophthalmology Konkuk University Medical Center Konkuk University School of Medicine Seoul Korea.) Choi Dong Gyu (Department of Ophthalmology Kangnam Sacred Heart Hospital Hallym University College of Medicine Seoul Korea.) Park Kyung-Ah (Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Jeon Hyeshin (Department of Ophthalmology Pusan National University Hospital Busan Korea.) Lee Byung Joo (Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Kim Seong-Joon (Department of Ophthalmology Seoul National University Hospital Seoul National University College of Medicine Seoul Korea.) Oh Sei Yeul (Department of Ophthalmology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Ahn Hyosook (Department of Ophthalmology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Chung Seung Ah (Department of Ophthalmology Ajou University School of Medicine Suwon Korea.) Kim Ungsoo Samuel (Department of Ophthalmology Chung-Ang University Gwangmyeong Hospital Chung-Ang University College of Medicine Gwangmyeong Korea.) Lee Haeng-Jin (Department of Ophthalmology Jeonbuk National University College of Medicine Jeonju Korea.) Lee Joo Yeon (Department of Ophthalmology Hallym University Sacred Heart Hospital Hallym University College of Medicine Anyang Korea.) Choi Youn Joo (Department of Ophthalmology Kangdong Sacred Heart Hospital Hallym University College of Medicine Seoul Korea.)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.38 No.12
발행연도
2023.3
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2023.38.e95

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초록· 키워드

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Background: To report the clinical manifestations of non-arteritic anterior ischemic optic neuropathy (NAION) cases after coronavirus disease 2019 (COVID-19) vaccination in Korea. Methods: This multicenter retrospective study included patients diagnosed with NAION within 42 days of COVID-19 vaccination. We collected data on vaccinations, demographic features, presence of vascular risk factors, ocular findings, and visual outcomes of patients with NAION. Results: The study included 16 eyes of 14 patients (6 men, 8 women) with a mean age of 63.5 ± 9.1 (range, 43–77) years. The most common underlying disease was hypertension, accounting for 28.6% of patients with NAION. Seven patients (50.0%) had no vascular risk factors for NAION. The mean time from vaccination to onset was 13.8 ± 14.2 (range, 1–41) days. All 16 eyes had disc swelling at initial presentation, and 3 of them (18.8%) had peripapillary intraretinal and/or subretinal fluid with severe disc swelling. Peripapillary hemorrhage was found in 50% of the patients, and one (6.3%) patient had peripapillary cotton-wool spots. In eight fellow eyes for which we were able to review the fundus photographs, the horizontal cup/ disc ratio was less than 0.25 in four eyes (50.0%). The mean visual acuity was logMAR 0.6 ± 0.7 at the initial presentation and logMAR 0.7 ± 0.8 at the final visit. Conclusion: Only 64% of patients with NAION after COVID-19 vaccination have known vascular and ocular risk factors relevant to ischemic optic neuropathy. This suggests that COVID-19 vaccination may increase the risk of NAION. However, overall clinical features and visual outcomes of the NAION patients after COVID-19 vaccination were similar to those of typical NAION.
#Coronavirus Disease 2019 (COVID-19) #Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) #Vaccination #Non-Arteritic Anterior Ischemic Optic Neuropathy

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