지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.1
- 수록면
- 1 - 13 (13page)
- DOI
- 10.1038/s12276-022-00921-x
이용수
초록· 키워드
오류제보하기
Chronic alcohol consumption often induces hepatic steatosis but rarely causes severe inflammation in Kupffer cells (KCs) despite the increased hepatic influx of lipopolysaccharide (LPS), suggesting the presence of a veiled tolerance mechanism. In addition to LPS, the liver is affected by several gut-derived neurotransmitters through the portal blood, but the effects of catecholamines on KCs have not been clearly explored in alcohol-associated liver disease (ALD). Hence, we investigated the regulatory roles of catecholamine on inflammatory KCs under chronic alcohol exposure. We discovered that catecholamine levels were significantly elevated in the cecum, portal blood, and liver tissues of chronic ethanol-fed mice. Increased catecholamines induced mitochondrial translocation of cytochrome P450 2E1 in perivenous hepatocytes expressing the β2-adrenergic receptor (ADRB2), leading to the enhanced production of growth differentiation factor 15 (GDF15). Subsequently, GDF15 profoundly increased ADRB2 expression in adjacent inflammatory KCs to facilitate catecholamine/ADRB2-mediated apoptosis. Single-cell RNA sequencing of KCs confirmed the elevated expression of Adrb2 and apoptotic genes after chronic ethanol intake. Genetic ablation of Adrb2 or hepatic Gdf15 robustly decreased the number of apoptotic KCs near perivenous areas, exacerbating alcohol-associated inflammation. Consistently, we found that blood and stool catecholamine levels and perivenous GDF15 expression were increased in patients with early-stage ALD along with an increase in apoptotic KCs. Our findings reveal a novel protective mechanism against ALD, in which the catecholamine/GDF15 axis plays a critical role in KC apoptosis, and identify a unique neuro-metabo-immune axis between the gut and liver that elicits hepatoprotection against alcohol-mediated pathogenic challenges.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Connecting Two 30Kc19α Monomers Using a Flexible Linker for Efficient Dimer Formation and Cell-penetration
한국생물공학회 학술대회
2021 .10
-
Linking Two 30Kc19α Monomers with a Peptide Linker for Efficient Dimerization and Cell-penetration
한국생물공학회 학술대회
2021 .04
-
Enhancing Viability of CHO Cells Using 30Kc19-30Kc6α
한국생물공학회 학술대회
2021 .04
-
Synergistic oxidation activity of lignolytic enzyme complex under catecholamine derived material as substrate
한국생물공학회 학술대회
2018 .04
-
KC-100 유무인 전환 비행시험
항공우주시스템공학회 학술행사 논문집
2024 .10
-
스마트건설 활성화를 위한 표준시방서 (KCS) 마련 연구
대한공간정보학회 학술대회
2022 .05
-
KC-100 소형항공기 개발 조종안정성 검증 비행시험 연구
항공우주시스템공학회 학술행사 논문집
2016 .05
-
Strong adhesion of poly(catecholamine) coatings induced by cation-π interactions
한국생물공학회 학술대회
2016 .04
-
Nanomechanics of Poly(Catecholamine) Coating in Aqueous Solutions
한국생물공학회 학술대회
2015 .10
-
CFD를 이용한 KCS의 가상 자유항주 시뮬레이션
한국전산유체공학회 학술대회논문집
2021 .11
-
슬로싱 하중 유형에 따른 KC-1 단열시스템의 구조응답에 관한 연구
대한기계학회 춘추학술대회
2015 .11
-
KC-100 개발과 성과
한국항공우주학회 학술발표회 초록집
2017 .04
-
KC-1 화물창 멤브레인의 두께 감소에 따른 구조 안전성 고찰
한국가스학회 학술대회논문집
2016 .11
-
The Strategy for Protein-based Direct Conversion Using 30Kc19 Protein
한국생물공학회 학술대회
2017 .04
-
Microwave-assisted oxidation of catecholamines for rapid preparation of multifunctional coatings
한국고분자학회 학술대회 연구논문 초록집
2015 .04
-
전기자동차용 완속, 고속 배터리 충전기의 KC 인증
한국에너지학회 학술발표회
2017 .04
-
Production of 30Kc19α Protein Nanoparticle for Drug Delivery
한국생물공학회 학술대회
2015 .10
-
A Study of comparison of sloshing pressure according to size of KC-1 CCS
한국가스학회 학술대회논문집
2016 .11
-
Catecholamine Chemistry Found in Mechanically Strong Grasshopper Mandibles
한국고분자학회 학술대회 연구논문 초록집
2016 .04
-
건축물 강구조공사 표준시방서(KCS-41-31-00)의 재·개정 지향목표
한국강구조학회 학술대회 발표집
2022 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0