지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
In this study, the surface of Polyetheretherketone (PEEK) disks was modified to have a hydrophilic surface by applying a coating of Polyethylene glycol (PEG), Hyaluronic acid(HA), and Poly-Dopamine(PDA). The investigation aimed to examine whether the coated surfaces showed enhanced bioactivity for orthopedic applications compared to the pure PEEK. The microstructure, surface characteristics, and wettability of PEEK coated with PEG, HA, and PDA were analyzed using scanning electron microscopy(SEM), FT-IR spectrophotometer, Roughness Measurement System, Micro-Vickers, and Contact angle measurement. The mechanical properties were analyzed using a tensile testing machine, while the MTT assay for cell activity was analyzed using a microplate reader to measure optical density. According to the SEM and FT-IR results, the composition and crystal structure of PEG, HA and PDA coated surface were verified. Also, roughness, hardness, and contact angle were all improved in the coating group compared to the pure PEEK. We checked the HepG2 cell proliferation by using MTT assay on 7th days. In MTT assay results, HepG2 cell proliferation was increased with time, at 7 days, cell viability on discs coated with PDA was significantly higher than pure PEEK, PEG, HA coated group. PDA coated PEEK exhibited the highest surface roughness, hardness, contact angle, and cell activity. The mechanical properties were not affected by the presence of the coating.
목차
Abstract
1. 서론
2. 실험조건 및 방법
3. 결과 및 토론
4. 결론
References
참고문헌 (42)
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F. M. Phillips, M. N. Tzermiadianos, L.I. Voronov, R.M. Havey, G. Carandang, S. M. Renner, D. M. Rosler, J. A. Ochoa, A. G. Patwardhan, Effect of the total facet arthroplasty system after complete laminectomy-facetectomy on the biomechanics of implanted a
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M. Niinomi, T. Hattori, S. Niwa, Material characteristics and biocompatibility of low rigidity titanium alloys for biomedical applications, Biomaterials in Orthopedics, 22 (2004) 41-62.
A. Warburton, S. J. Girdler, C. M. Mikhail, A. Ahn, S. K. Cho, Biomaterials in spinal implants: a review, Neurospine, 17 (2020) 101-110.
F. M. Phillips, M. N. Tzermiadianos, L.I. Voronov, R.M. Havey, G. Carandang, S. M. Renner, D. M. Rosler, J. A. Ochoa, A. G. Patwardhan, Effect of the total facet arthroplasty system after complete laminectomy-facetectomy on the biomechanics of implanted a
M. E. Majd, M. Vadhva, R. T. Holt, Anterior cervical reconstruction using titanium cages with anterior plating, Spine, 24 (1999) 1604-1610.
M. Niinomi, T. Hattori, S. Niwa, Material characteristics and biocompatibility of low rigidity titanium alloys for biomedical applications, Biomaterials in Orthopedics, 22 (2004) 41-62.
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