지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.8
- 수록면
- 682 - 697 (16page)
이용수
초록· 키워드
오류제보하기
BACKGROUND/OBJECTIVES: Tibetan tea is a kind of dark tea, due to the inherent complexity of natural products, the chemical composition and beneficial effects of Tibetan tea are not fully understood. The objective of this study was to unravel the composition of Tibetan tea using knowledge-guided multilayer network (KGMN) techniques and explore its potential antioxidant and hypolipidemic mechanisms in mice.
MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH₂O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method.
RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism.
CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.
MATERIALS/METHODS: The C57BL/6J mice were continuously gavaged with Tibetan tea extract (T group), green tea extract (G group) and ddH₂O (H group) for 15 days. The activity of total antioxidant capacity (T-AOC) and superoxide dismutase (SOD) in mice was detected. Transcriptome sequencing technology was used to investigate the molecular mechanisms underlying the antioxidant and lipid-lowering effects of Tibetan tea in mice. Furthermore, the expression levels of liver antioxidant and lipid metabolism related genes in various groups were detected by the real-time quantitative polymerase chain reaction (qPCR) method.
RESULTS: The results showed that a total of 42 flavonoids are provisionally annotated in Tibetan tea using KGMN strategies. Tibetan tea significantly reduced body weight gain and increased T-AOC and SOD activities in mice compared with the H group. Based on the results of transcriptome and qPCR, it was confirmed that Tibetan tea could play a key role in antioxidant and lipid lowering by regulating oxidative stress and lipid metabolism related pathways such as insulin resistance, P53 signaling pathway, insulin signaling pathway, fatty acid elongation and fatty acid metabolism.
CONCLUSIONS: This study was the first to use computational tools to deeply explore the composition of Tibetan tea and revealed its potential antioxidant and hypolipidemic mechanisms, and it provides new insights into the composition and bioactivity of Tibetan tea.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
In-silico annotation of the chemical composition of Tibetan tea and its mechanism on antioxidant and lipidlowering in mice
Nutrition Research and Practice
2023 .08
-
Research of the Textile Pattern Design based on the Tibetan Traditional Costumes
복식
2022 .06
-
Impact of Tibetan Plateau sensible heat on heat waves in South Korea
한국기상학회 학술대회 논문집
2017 .10
-
Season-dependent Effect of Tibetan Plateau on Northern Hemispheric Blocking Frequency
한국기상학회 학술대회 논문집
2015 .10
-
Dynamical control of the Tibetan Plateau on the East Asian summer monsoon
한국기상학회 학술대회 논문집
2019 .10
-
Seasonally varying effect of the Tibetan Plateau on Northern Hemispheric blocking frequency and amplitude
한국기상학회 학술대회 논문집
2016 .04
-
Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice
Nutrition Research and Practice
2016 .10
-
Blueberry, blackberry, and blackcurrant differentially affect plasma lipids and pro-inflammatory markers in diet-induced obesity mice
Nutrition Research and Practice
2016 .10
-
티베트 복식 문양에 나타난 종교적 상징성
복식
2016 .01
-
Pear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation
Nutrition Research and Practice
2017 .06
-
Pear pomace ethanol extract improves insulin resistance through enhancement of insulin signaling pathway without lipid accumulation
Nutrition Research and Practice
2017 .06
-
The effects of Momordica charantia on obesity and lipid profiles of mice fed a high-fat diet
Nutrition Research and Practice
2015 .10
-
The effects of Momordica charantia on obesity and lipid profiles of mice fed a high-fat diet
Nutrition Research and Practice
2015 .10
-
Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice
Nutrition Research and Practice
2022 .10
-
Green perilla leaf extract ameliorates long-term oxidative stress induced by a high-fat diet in aging mice
Nutrition Research and Practice
2022 .10
-
Weak upstream westerly wind attracts Western North Pacific typhoon tracks to west
한국기상학회 학술대회 논문집
2022 .04
-
Effects of quercetin derivatives from mulberry leaves : Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice
Nutrition Research and Practice
2015 .04
-
Effects of quercetin derivatives from mulberry leaves : Improved gene expression related hepatic lipid and glucose metabolism in short-term high-fat fed mice
Nutrition Research and Practice
2015 .04
-
The tibetan plateau uplift is crucial for eastward propagation of Madden-Julian Oscillation
한국기상학회 학술대회 논문집
2019 .10
-
Effects of Resistant Starch Supplementation on Glucose Metabolism, Lipid Profile, Lipid Peroxidation Marker, and Oxidative Stress in Overweight and Obese Adults: Randomized, Double-Blind, Crossover Trial
Clinical Nutrition Research
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0102-2023-594-001907056