A nationwide study of compliance of venoactive drugs in chronic venous disease patients

Hyangkyoug Kim; Sungsin Cho; Kwangjin Lee; Seung Hwan Lee; Jin Hyun Joh

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자료유형: 학술저널

저자정보: Hyangkyoug Kim (Kyung Hee University School of Medicine) Sungsin Cho (Kyung Hee University School of Medicine) Kwangjin Lee (Kyung Hee University School of Medicine) Seung Hwan Lee (Kyung Hee University School of Medicine) Jin Hyun Joh (Kyung Hee University School of Medicine)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.104 No.5

발행연도: 2023.5

수록면: 288 - 295 (8page)

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Purpose: Venoactive drugs are widely used to improve the symptoms and signs of chronic venous disease. This study aimed to analyze the rate of adverse events after venoactive drug prescription and subsequent compliance and switching rates.
Methods: Using the National Health Insurance Service database, individuals with at least one chronic venous disease code between January 2009 and December 2019 were identified, and 30% (2,216,780 individuals) of these were sampled. Finally, 1,551,212 patients were included, and we analyzed adverse events, compliance, and switching rates with 8 venoactive drugs, including Vitis vinifera extract, naftazone, micronized purified flavonoid fraction, Vitis vinifera leaf extract, diosmin, diobsilate calcium, bilberry fruit dried extract, and sulodexide.
Results: The most commonly prescribed venoactive drug was Vitis vinifera extract (72.2%), followed by sulodexide (9.3%), and Vitis vinifera leaf dry extract (8.2%). Adverse event rates were significantly lower in the naftazone and diosmin groups (P = 0.001 and P = 0.002, respectively) and significantly higher in the Vitis vinifera leaf dry extract group (P = 0.009). Drug adherence to sulodexide was the highest throughout the study period, followed by billberry extract and dobesilate (all P ＜ 0.001). For most drugs, the drug switching rate was low (＜5.0%).
Conclusion: Vitis vinifera extract was the most commonly prescribed venoactive drug in Korea, and drug adherence to sulodexide was the highest among all venoactive drugs. The adverse event rates were significantly lower in the naftazone and diosmin groups.

#Chronic disease #Compliance #Drug-related side effects and adverse reactions #Veins #Venoactive drug

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