지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 63 - 71 (9page)
이용수
초록· 키워드
오류제보하기
Genome-wide association study (GWAS) is a powerful tool for identifying the genetic causes of various diseases. This study was conducted to identify genomic variation in Maltese dog genomes associated with degenerative mitral valve disease (DMVD) development and to evaluate the association of each biological condition with DMVD in Maltese dogs. DNA was extracted from blood samples obtained from 48 Maltese dogs (32 with DMVD and 16 controls). Genome-wide single nucleotide polymorphism (SNP) genotyping was performed. The top 30 SNPs from each association of various conditions and genetic variations were mapped to their gene locations. A total of 173,662 loci were successfully genotyped, with an overall genotype completion rate of 99.41%. Quality control analysis excluded 46,610 of these SNPs. Manhattan plots were produced using allelic tests with various candidate clinical conditions. A significant peak of association was observed between mitral valve prolapse (MVP) and SNPs on chromosome 17. The present study revealed significant SNPs in several genes associated with cardiac function, including PDZ2, Armadillo repeat protein detected in velo-cardio-facial syndrome, catenin (cadherin-associated protein) alpha 3, low-density lipoprotein receptor class A domain containing protein 4, and sterile alpha motif domain containing protein 3. To our knowledge, this is the first study of a genetic predisposition to DMVD in Maltese dogs. Although only a limited number of cases were analyzed, these data could be the basis for further research on the genetic predisposition to MVP and DMVD in Maltese dogs.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Polymorphism in the serotonin transporter protein gene in Maltese dogs with degenerative mitral valve disease
Journal of Veterinary Science
2018 .01
-
Familial mitral valve prolapse in a Maltese dog family
Journal of Biomedical and Translational Research
2015 .01
-
Rare Case of Unileaflet Mitral Valve
Journal of Cardiovascular Imaging
2016 .01
-
Massive Hemoptysis due to Acute Mitral Regurgitation with Sporadic Primary Mitral Valve Prolapse
Acute and Critical Care
2015 .01
-
Ruptured Mitral Valve Aneurysm: A Rare Complication of Mitral Valve Endocarditis
Journal of Cardiovascular Imaging
2019 .01
-
Successful mitral repair in dogs by mitral annuloplasty using Hegar dilator: two case reports
Journal of Veterinary Science
2022 .01
-
Searching for ‘the method’ in the assessment of complex mitral valve
Journal of Cardiovascular Imaging
2024 .08
-
Two women presenting aborted sudden cardiac arrest as the first event of mitral valve disease
Acute and Critical Care
2019 .01
-
A Modified Echocardiographic Classification of Mitral Valve Regurgitation Mechanism: The Role of Three-dimensional Echocardiography
Journal of Cardiovascular Imaging
2019 .01
-
Echocardiographic parameters and indices in 23 healthy Maltese dogs
Journal of Veterinary Science
2021 .09
-
Persistent Fever in a Patient With Mechanical Mitral Valve Replacement
Journal of Cardiovascular Imaging
2023 .01
-
수술 고위험군 승모판 폐쇄부전증 치료를 위한 MitraClip: 안전성 유효성에 대한 문헌고찰
보건의료기술평가
2016 .06
-
Unmasked Obstructive Hypertrophic Cardiomyopathy after Mitral Valve Repair for Severe Mitral Regurgitation
Korean Circulation Journal
2020 .01
-
Percutaneous Edge-to-Edge Mitral Valve Repair
Korean Circulation Journal
2020 .01
-
Congenital mitral valve stenosis in a Chinchilla cat
Korean Journal of Veterinary Research(대한수의학회지)
2016 .10
-
Mitral Valve Leaflet Aneurysm-Dynamic CT and Echocardiographic Appearances
Cardiovascular Imaging Asia
2019 .01
-
The medical management of mitral stenosis in a Bull Terrier
한국가축위생학회지
2023 .03
-
A Congenital Gerbode Defect associated with a Rare Structural Abnormality of the Mitral Valve Diagnosed in an Adult Patient
Korean Circulation Journal
2016 .01
-
Unusually Early Recurrence of Mitral Valve Myxoma in a Child
Korean Circulation Journal
2021 .01
-
Never Too Old for a Congenital Heart Disease: A Case of a Unileaflet Mitral Valve in a 76-year-old Man
Journal of Cardiovascular Imaging
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-528-001324331