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이 논문의 연구 히스토리 (2)
2012
Effect of dietary zinc on experimental induction of colonic preneoplastic lesions in mice fed low iron diet
강봉수
,
Hyunji Pa
,
k
외 8명
예방수의학회지
2012.03
학술저널
Protective effect of dietary zinc against colonic preneoplastic lesion induced by azoxymethane and dextran sodium sulfate in mice fed high iron diet
강봉수
,
박현지
,
김당영
외 6명
한국실험동물학회 학술발표대회 논문집
2012.02
학술대회자료
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초록· 키워드
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Both iron-deficient and zinc-sufficient diets have been known to be associated with a decreased risk of colon cancer. We investigated that effect of dietary zinc on the formation of colonic aberrant crypt foci (ACF) induced by azoxymethane (AOM) followed by dextran sodium sulfate in iron-deficient mice. Five-week old ICR mice were acclimated for 1 week and fed on iron-deficient diet (4.50 ppm iron) with three different zinc levels (0.01, 0.1, and 1.0 ppm) for 12 weeks. The total number of aberrant crypt (AC) and ACF was measured in the colonic mucosa after methylene blue staining. The total ACF numbers of low Zn (LZn), medium Zn (MZn) and high Zn (HZn) diet groups were 10.00 ± 2.67, 8.78 ± 3.12, and 7.96 ± 2.44, respectively and there were no significant differences among the groups. However, the total AC numbers of HZn (27.07 ± 3.88) and MZn (26.39 ± 5.59) diet groups were significantly low compared to LZn (22.57 ± 5.09) diet group (p<0.01). Cytosolic SOD activity was the highest in LZn diet group. But thiobarbituric acid-reactive substances level in liver was also the highest in LZn diet group compared to other groups. There is no difference in cell proliferation in mucous membrane among the groups, while apoptotic positive cells were increased in the HZn diet group. The high zinc diet exhibited decreased β-catenin-stained areas on the mucous membrane of colon compared to the LZn or MZn diet group. These findings indicate that dietary zinc might exert a modulating effect on development of ACF/AC in the mice with iron-deficient status.
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참고문헌 (32)
참고문헌 신청
Bettger WJ / 1980 / Interaction of zinc and vitamin E in the chick / Proc Soc Exp Biol Med 163:432~436
Bird RP / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 37:147~151
Chang WW / 1984 / Histogenesis of colon cancer in experimental animals / Scand J Gastroenterol Suppl 104:27~43
Corpet DE / 2005 / How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men / Eur J Cancer 41:1911~1922
Dani V / 2007 / Chemopreventive potential of zinc in experimentally induced colon carcinogenesis / Toxicol Lett 171:10~18
Bird RP / 1987 / Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings / Cancer Lett 37:147~151
Chang WW / 1984 / Histogenesis of colon cancer in experimental animals / Scand J Gastroenterol Suppl 104:27~43
Corpet DE / 2005 / How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men / Eur J Cancer 41:1911~1922
Dani V / 2007 / Chemopreventive potential of zinc in experimentally induced colon carcinogenesis / Toxicol Lett 171:10~18
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