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논문 기본 정보

자료유형
학술저널
저자정보
Choi Jin-Ha (The University of Texas at Austin) Lee Jaewon (The University of Texas at Austin) Shin Woojung (The University of Texas at Austin) 최정우 (서강대학교) Kim Hyun Jung (The University of Texas at Austin)
저널정보
나노기술연구협의회 Nano Convergence Nano Convergence Vol.3 No.24
발행연도
2016.10
수록면
1 - 10 (10page)
DOI
10.1186/s40580-016-0084-8

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Nanotechnology and bioengineering have converged over the past decades, by which the application of multi-functional nanoparticles (NPs) has been emerged in clinical and biomedical fields. The NPs primed to detect disease-specific biomarkers or to deliver biopharmaceutical compounds have beena validated in conventional in vitro culture models including two dimensional (2D) cell cultures or 3D organoid models. However, a lack of experimental models that have strong human physiological relevance has hampered accurate validation of the safety and functionality of NPs. Alternatively, biomimetic human “Organs-on-Chips” microphysiological systems have recapitulated the mechanically dynamic 3D tissue interface of human organ microenvironment, in which the transport, cytotoxicity, biocompatibility, and therapeutic efficacy of NPs and their conjugates may be more accurately validated. Finally, integration of NP-guided diagnostic detection and targeted nanotherapeutics in conjunction with human organs-on-chips can provide a novel avenue to accelerate the NP-based drug development process as well as the rapid detection of cellular secretomes associated with pathophysiological processes.

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