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자료유형
학술저널
저자정보
방혜원 (가톨릭대학교 의과대학 성빈센트병원 외과) 임승택 (가톨릭대학교 의과대학 성빈센트병원 외과) 전예원 (가톨릭대학교 의과대학 성빈센트병원 외과) 서영진 (가톨릭대학교 의과대학 성빈센트병원 외과)
저널정보
한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제3권 제2호
발행연도
2015.12
수록면
37 - 42 (6page)
DOI
http://dx.doi.org/10.14449/jbd.2015.3.2.37

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Purpose: As there is growing evidence that the vitamin D status is correlated with breast cancer prognosis, in this study, we investigated the correlation between serum 1,25-dihydroxyvitamin D levels and the prognosis of patients with breast cancer in a Korean cohort. Methods: We performed a retrospective analysis of 436 Korean patients with breast cancer who were diagnosed between January 2000 and December 2008. According to the serum 1,25-dihydroxyvitamin D levels, the patients were divided into the following two groups: group 1 (<29.75 ng/mL) and group 2 (≥29.75 ng/mL). Survival curves were obtained by using the Kaplan-Meier method. Univariate and multivariate analyses were also conducted to assess the independent prognostic significance of serum 1,25-dihydroxyvitamin D levels. Results: During a mean period of 84.66±29.29 months, 51 patients experienced tumor recurrence and 22 patients died. On survival analysis, group 1 showed poorer disease-free survival, especially for patients with luminal type breast cancer. Univariate and multivariate analyses showed that the 1,25-dihydroxyvitamin D status was a significant prognostic factor for disease-free survival, only in patients with luminal type breast cancer. Conclusion: The serum 1,25-dihydroxyvitamin D status can influence disease-free survival in Korean patients with breast cancer, particularly in those with luminal type breast cancer.

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