지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Cefepime is fourth generation class, broad-spectrum cephalosporin. In contrast to older cephalosporins, cefepime penetrates the gram-negative cell more rapidly, targets multiple essential penicillin-binding proteins, and escapes the effects of many beta-lactamases due to the enzymes’ low affinity for the drug. However, it should be used judiciously because unnecessary, improper, and prolonged use may lead to the emergence of cefepime-insensitive bacteria and risk decline in its efficacy.
Therefore, this study was performed to evaluate the use of cefepime and its efficacy.
We retrospectively analyzed medical records of patients who received cefepime at Chonbuk National University Hospital, from January 2011 to July 2011.
As a result, 169 cases were studied; the justification of use showed a high rate of appropriate use 161 cases(95.3%). A majority of the critical(process) indicators also showed a high rate of appropriate use 126~164 cases(74.6~100%). The dosage of cefepime was appropriate in 122 cases(72.2%). Duration of therapy was appropriate in 100% of patients with neutropenia, but other cases were lower.
Complications occurred in 35 cases, including nephrotoxicity(9 cases), hepatotoxicity(4 cases), gastrointestinal effects(8 cases), hematologic effects(5 cases), fever(3 cases), skin reactions(5 cases) and neurotoxicity(1 case). In outcome measures, the total therapeutic response rate showed 60.9%.
Cefepime was being used for appropriate reasons, but it was not being well monitored.
Since the improper use of antibiotics can lead to an increase of multidrug-resistant bacterias, increased safety measures could be taken by authorized clinical pharmacists to prescribe antibiotics for proper use and ongoing monitoring. Additional studies will also need to be considered for a wider variety of clinical data.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Boryung / Maxipime (cefepime) insert paper
Angelescu M. / 2001 / Cefepime (maxipime), large spectrum 4th generation cephalosporin, resistant to beta-lactamases / Chirurgia (Bucur) 96(6):547~552
Sanders C. C. / 1993 / Cefepime: the next generation? / Clinical Infectious Diseases 17(3):369~379
Neu H. C. / 1986 / The activity of BMY 28142 a new broad spectrum β-lactamase stable cephalosporin / J. Antimicrob. Chemother 17(4):441~452
Bellido B. / 1991 / Novel method for measurement of outer membrane permeability to new beta-lactams in intact Enterobacter cloacae cells / Antimicrob Agents Chemother 35(1):68~72
Angelescu M. / 2001 / Cefepime (maxipime), large spectrum 4th generation cephalosporin, resistant to beta-lactamases / Chirurgia (Bucur) 96(6):547~552
Sanders C. C. / 1993 / Cefepime: the next generation? / Clinical Infectious Diseases 17(3):369~379
Neu H. C. / 1986 / The activity of BMY 28142 a new broad spectrum β-lactamase stable cephalosporin / J. Antimicrob. Chemother 17(4):441~452
Bellido B. / 1991 / Novel method for measurement of outer membrane permeability to new beta-lactams in intact Enterobacter cloacae cells / Antimicrob Agents Chemother 35(1):68~72
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