지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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In the present study, the effects of treadmill exercise on expression of myostatin and follistatin protein expression of old aged rats according to skeletal muscle types. 16-month-old male rats(n=12) and male Sprague-Dwaley (n=12) were used as the old-aged groups. The Sprague-Dawley rats were randomly divided into 4 groups(n=6 in each group), as follows: the old-aged female group(n=6), the old-aged female and exercise group(n=6), the old-aged male group(n=6), old-aged male and exercise group(n=6). The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 4 weeks. The load of exercise consisted of running at a speed of 2 m/min for the first 5 min, 5 m/min for the next 25 min, with a 0° inclination. The expression of myostatin in soleus muscle was lower in the old aged male rats compared with old aged female rats. In contrast, the expression of follistatin in soleus muscle was higher in the old aged male rats compared to old aged female rats. Treadmill exercise decreased expression of myostatin and, increased expression of follistatin in the soleus muscle. The expression of myostatin in gastrocnemius muscle was lower in the old aged female rats compared with old aged male rats. In contrast, the expression of follistatin in gastrocnemius muscle was not statistically significant. Treadmill exercise decreased expression of myostatin, however, the expression of follistatin was increased by treadmill exercise in the gastrocnemius muscle. Here in this study, we showed that treadmill exercise is a very useful strategy for preventing loss of muscle by inhibiting expression of myostatin and enhancing expression of follistatin.
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참고문헌 (36)
참고문헌 신청
유형준 / 2000 / 노화와 비만 / 대한비만학회지 9(1):43~52
Amthor, H. / 2002 / Follistatin regulates bone morphogenetic protein-7(BMP-7)activity to stimulate embryonic muscle growth / Developmental Biology 243:115~127
Amthor, H. / 2002 / The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis / Developmental Biology 251:241~257
Amthor, H. / 2004 / Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis / Developmental Biology 270:19~30
Aoki, M. S. / 2009 / Expression of genes related to myostatin signaling during rat skeletal muscle longitudinal growth / Muscle & Nerve 40:992~999
Amthor, H. / 2002 / Follistatin regulates bone morphogenetic protein-7(BMP-7)activity to stimulate embryonic muscle growth / Developmental Biology 243:115~127
Amthor, H. / 2002 / The regulation and action of myostatin as a negative regulator of muscle development during avian embryogenesis / Developmental Biology 251:241~257
Amthor, H. / 2004 / Follistatin complexes Myostatin and antagonises Myostatin-mediated inhibition of myogenesis / Developmental Biology 270:19~30
Aoki, M. S. / 2009 / Expression of genes related to myostatin signaling during rat skeletal muscle longitudinal growth / Muscle & Nerve 40:992~999
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