Preoperative Plasma Fibrinogen Level Is a Useful Predictor of Adjacent Organ Involvement in Patients with Advanced Gastric Cancer

이상억; Jun Ho Lee; Keun Won Ryu; 남병호; 조수정; Jong Yeul Lee; Chan Gyoo Kim; 최일주; 국명철; Sook Ryun Park; 김영우

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자료유형: 학술저널

저자정보: 이상억 (건양대학교) Jun Ho Lee (National Cancer Center) Keun Won Ryu (National Cancer Center) 남병호 (국립암센터) 조수정 (국립암센터) Jong Yeul Lee (National Cancer Center) Chan Gyoo Kim (National Cancer Center) 최일주 (국립암센터) 국명철 (국립암센터) Sook Ryun Park (National Cancer Center) 김영우 (국립암센터)

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제12권 제2호

발행연도: 2012.6

수록면: 81 - 87 (7page)

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Purpose: The aim of the present study was to assess the association between the pre-operative plasma fibrinogen level and the adjacent organ involvement in advanced gastric cancer. Materials and Methods: A total of 923 pre-operative plasma samples were obtained from 923 patients diagnosed clinically as having advanced gastric cancer, and fibrinogen levels were measured by immunoassay. Associations between fibrinogen levels and clinicopathologic findings (depth of tumor, adjacent organ involvement, and lymph node metastasis), along with survival were examined by univariate and multivariate analyses. Results: Tumor size, tumor depth, and the presence of lymph node metastasis were found to be positively correlated with the preoperative plasma fibrinogen levels (P<0.001). Fifty (5.4%) patients had adjacent organ involvement. Lymphatic invasion (P<0.001), tumor size (P<0.001), clinical T (depth of invasion) stage (P<0.001), and clinical nodal stage (P=0.018) were found to be associated with adjacent organ involvement. Univariate and multivariate regression analyses showed that a preoperatively elevated plasma fibrinogen level was associated with adjacent organ involvement (P<0.001, 0.028), and Kaplan-Meier analysis showed that it was associated with poorer survival (P<0.001). Conclusions: Plasma fibrinogen was found to be a clinically useful marker of adjacent organ involvement and overall survival. When a high fibrinogen level is encountered, preoperatively, adjacent organ involvement should be suspected in clinically advanced gastric cancer.

#Fibrinogen #Gastrectomy

참고문헌 (26)

참고문헌 신청

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