Pathogenesis and Bone Resorption in Acquired Cholesteatoma: Current Knowledge and Future Prospectives

Mahmood A. Hamed; Seiichi Nakata; Ramadan H. Sayed; Hiromi Ueda; Badawy S. Badawy; Yoichi Nishimura; Takuro Kojima; Noboru Iwata; Ahmed R. Ahmed; Khalid Dahy; Naoki Kondo; Kenji Suzuki

doi:http://dx.doi.org/10.21053/ceo.2015.01662

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자료유형: 학술저널

저자정보: Mahmood A. Hamed (Sohag Faculty of Medicine Sohag University) Seiichi Nakata (Sohag Faculty of Medicine Sohag University) Ramadan H. Sayed (Sohag Faculty of Medicine Sohag University) Hiromi Ueda (Aichi Medical University Japan) Badawy S. Badawy (Sohag Faculty of Medicine Sohag Univers) Yoichi Nishimura (Sohag Faculty of Medicine Sohag Univers) Takuro Kojima (Sohag Faculty of Medicine Sohag Univers) Noboru Iwata (Sohag Faculty of Medicine Sohag Univers) Ahmed R. Ahmed (Sohag University Sohag Egypt) Khalid Dahy (Sohag Faculty of Medicine Sohag Univers) Naoki Kondo (Fujita Health University) Kenji Suzuki (Sohag Faculty of Medicine Sohag Univers)

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제9권 제4호

발행연도: 2016.12

수록면: 298 - 308 (11page)

DOI: http://dx.doi.org/10.21053/ceo.2015.01662

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Cholesteatoma is a cystic non tumorous lesion of the temporal bone that has the ability to destroy nearby structures by its power to cause bone resorption and as a result, fatal complications prevail. We aimed to conduct a comprehensive review for pathogenesis of acquired cholesteatoma, bone resorption mechanisms, and offer a future vision of this serious disease. We have reviewed different theories for pathogenesis of acquired cholesteatoma including the most relevant and updated ones with special emphasis on the mechanisms of bone resorption through Medline/PubMed research using the keywords ‘aetiopathogenesis, bone resorption, acquired cholesteatoma, temporal bone, and cytokines.’ In order to strengthen our study, we searched the reference lists of identified reviews. Cholesteatoma is a subject of debate among otolaryngologists since it was prescribed firstly. Over many decades, several theories were postulated for aetiopathogenesis of cholesteatoma with a tendency to follow more than one theory to explain the proper nature of that disease. Until now, the mechanism of bone resorption has yet to be more clarified. In the last century, a leap has occurred in the field of biomolecular cholesteatoma research which improved our knowledge about its pathophysiology and bone destructive mechanism. However, surgery is still the only available treatment. We conclude that discovery of new therapeutic choices for cholesteatoma other than surgery by the use of anti-growth, anti-proliferative, apoptotic agents as well as medications that antagonize osteoclastogenesis should be the main concern in the future clinical and experimental research work. Also, searching for predictors of the aggressiveness of cholesteatoma can affect the timing of intervention and prevent occurrence of complications.

#Pathogenesis #Bone Resorption #Cholesteatoma #Acquired #Temporal Bone #Cytokines

참고문헌 (140)

참고문헌 신청

Olszewska E. / 2004 / Etiopathogenesis of cholesteatoma / Eur Arch Otorhinolaryngol 261(1):6~24

Soldati D. / 2001 / Knowledge about cholesteatoma, from the first description to the modern histopathology / Otol Neurotol 22(6):723~730

Dornelles C. / 2005 / Some considerations about acquired adult and pediatric cholesteatomas / Braz J Otorhinolaryngol 71(4):536~545

Kuo CL / 2015 / Etiopathogenesis of acquired cholesteatoma : prominent theories and recent advances in biomolecular research / Laryngoscope 125(1):234~240

Kuo CL. / 2015 / Updates and knowledge gaps in cholesteatoma research / Biomed Res Int 2015:854024

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