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논문 기본 정보

자료유형
학술저널
저자정보
박선행 (한국한의학연구원) 성윤영 (한국한의학연구원) 장설 (한국한의학연구원) 이시우 (한국한의학연구원) 김홍준 (우석대학교) 김호경 (한국한의학연구원)
저널정보
대한예방한의학회 대한예방한의학회지 대한예방한의학회지 제20권 제3호
발행연도
2016.12
수록면
55 - 65 (11page)

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Objectives: Mibyeong is a korea medicine have original concept of the disease. However, no previous report has effect of mibyeong herbal medicine in fatigue types of mibyeong. This study investigated the question of whether Dang Gui Bo Hyul-tang(DGBHT) of effect on fatigue types of Mibyeong. Methods: C57BL/6 mice were randomaly divided into three group (n=10). The mice were then group (1) Nocontrol, (2) Restraunt stress(veh), (3) Dang Gui Bo Hyul-tang 200mg/kg. The administered Dang Gui Bo Hyul-tang 200mg/kg or distilled water (orally) 1 hr prior to daily exposure to repeated restraint stress (2 h) for 15 days. The performed behavior test ( Mechanical hyperalgesia test,, Open-field test, Forced swimming test, Sucrose preference test and immunostaining and biochemical measured in serum. Results: Stress fatigue induced mices significantly increased lethargic, hyperalgesia through behavior test ( Mechanical hyperalgesia test (decrease 43%), Open-field test (4,809± 226.13 ㎝ vs. 3121 ± 226.64 ㎝), Forced s wi m mi n g t e s t (11.45 ± 3.96 vs. 79.10 ± 8.12 sec), Sucrose preference test (decrease 58%)). In addition, chronic fatigue model evidently increased corticosterone level (122.54±18.88 vs. 186.94±18.26 ng/ml), AST level (46.22±3.23 vs.31.40±3.86 U/L), ALT level (38.78±5.72 vs. 17.60±1.30), liver necrosis, lateral ventricle size. These alterations were significantly ameliorated by DGBHT. DGBHT significantly attend the elevated serum concentrations of corticosterone (155.90±6.29 ng/ml), AST (31.40±3.86 U/L), ALT (17.60±1.30 U/L). Moreover, DGBHT improved lethargic, hyperalgesia when compared the stress fatigue ( Mechanical hyperalgesia test (improve 28%), Open-field test (4,038 ± 615.81 cm), Forced swimming test (7.56 ± 1.88 sec), Sucrose preference test (increase 21%) Conclusions: Theses result suggest that DGBHT have improved lethargic, hyperalgesia and fatigue-associated hormone and liver protective on stress fatigue model. It will be necessary to research to present evidences on benefits and effects of Korean medical treatment for Mibyeong through clinical researches based on benefits and effects of those animal models.

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