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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 117 - 130 (14page)
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초록· 키워드
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Objective : This study was designed to investigate the effects of non fermented Zizyphus. jujuba mixture (mixed fruit and leaf : ZM) and fermented Z. jujuba mixture(FZM) on fed high-fat diet induced hyperlipidemic rats for development medicinal food.
Method : The extracts prepared for Zizyphus. jujuba mixture(ZM) and fermented Z. jujuba mixture(FZM) with Lactobacillus plantarum and Saccharomyces cerevisiae. Experimental group was divided into normal control group(NC group) and high fat diet groups. The high fat diet groups fed high fat diet 2 weeks after was sub-divided into high fat diet control group(HC group), high fat diet positive control group(HPC group), non fermented Z. jujuba mixture extract group(ZM group) and fermented Z. jujuba mixture extract group(FZM group). NC and HC group was orally administerd of 0.9% saline, HPC group administerd lovastatin diluted in 0.9% saline at a dose of 10 ㎎/㎏ BW, ZM and FZM groups was administerd each extracts diluted in 0.9% saline at a dose of 300 ㎎/㎏ BW once a day on a fixed time for 4 weeks. In the present study we measured organ weight, epididymal fat tissue weight, concentration of serum lipids, hepatic lipids, MDA contents in liver tissue and metabolic variables in serum.
Results : ZM and FZM suppressed testis weight loss and FZM decreased epididymal fat tissue weight to level of NC group in high-fat diets. ZM and FZM did not influence on serum cholesterol level, but prominently decreased serum triglyceride concentration compared with HC group, and FZM diminished hepatic triglyceride same as serum. ZM and FZM did not impair liver and kidney function and influence positive effects through by suppression of elevation lipid level.
Conclusion : These results suggested that Z. jujuba mixture(ZM, FZM) should be useful developing medicinal food for prevention and improvement of hyperlipidemia and FZM is more suitable agent than ZM.
목차
등록된 정보가 없습니다.
참고문헌 (61)
참고문헌 신청
Na HS / 1996 / Effect of Jujube Methanol Extract on the Hepeatoxicity in CCl4-Treated Rats. / J. Korean Soc. Food Sci. Nutr 25:893~855
Pryor WA / 1986 / Oxy-radicals and related species : their formation, lifetimes, and reactions / Annu. Rev. Physiol 48:657~667
Shon MY / 2007 / Antioxidant and anticancer activities of Poria cocos and Machilus thunbergii fermented with Mycelial Mushrooms / Food Ind. Nutr 12:51~57
정용준 / 2007 / 발효한약추출물 HP-1이 알코올을 투여한 쥐의 알코올 대사에 미치는 영향 / 동의생리병리학회지 21(2):387~391
전국한의학대학 공동교재편찬위원회 / 2004 / 본초학 / 영림사 :588~589
Pryor WA / 1986 / Oxy-radicals and related species : their formation, lifetimes, and reactions / Annu. Rev. Physiol 48:657~667
Shon MY / 2007 / Antioxidant and anticancer activities of Poria cocos and Machilus thunbergii fermented with Mycelial Mushrooms / Food Ind. Nutr 12:51~57
정용준 / 2007 / 발효한약추출물 HP-1이 알코올을 투여한 쥐의 알코올 대사에 미치는 영향 / 동의생리병리학회지 21(2):387~391
전국한의학대학 공동교재편찬위원회 / 2004 / 본초학 / 영림사 :588~589
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