지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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In this study, a test for the immunity control effect by Chamaecyparis Obtusa Leaves(COL) extracts on NC/Nga mice as the models for atopic dermatitis was conducted with the following results. The test on the internal toxicity tests for the liver and the kidney showed that,as for the test group with COL, all of the measurement for ALT(Alanine transaminase), AST(Aspartate transaminase), BUN(Blood urea nitrogen), Creatinine were within the normal range. Also, the immunity rate of CD4+, B220+/CD23+, CD11b+/Gr-1+within PBMC showed a significant decrease compared to that of the control group. The cytokine within the blood serum, that is, IL-5, L-13, and IL-17showed a decreased compared to the control group. Especially, the generation of Histamine decreased with statistical significance. Also,cytokine IL-4 within the spleen cells that were activated by CD3/CD28 appeared to decrease, especially with a significant decrease in IFN-γ. In addition, the immune cells in Dorsal Skin, namely CD3+, CD11b+/Gr-1+, CD11b+/Gr-1, as well as the generation of the cytokine in the skin cells, IL-5, IL-13 as well as mRNA all decreased with statistical significance. The dermatitis appearance index of NC/Nga mice also decreased significantly, with a relative decrease in the permeation of the white cells and the thickness of epidermis and dermis. The above mentioned results indicated that the extracts of COL was effective in improving the symptoms of atopic dermatitis through various immunity control mechanisms through experiments.
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