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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 166 - 173 (8page)
- DOI
- 10.1186/s40824-016-0070-6
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초록· 키워드
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Background: Controlling the fate of mesenchymal stems cells (MSCs) including proliferation, migration and differentiation has recently been studied by many researchers in the tissue engineering field. Especially, recruitment of stem cells to injury sites is the first and crucial step in tissue regeneration. Although significant progress has been made in the chemotactic migration of MSCs, MSC migration in three dimensional environments remains largely unknown. We developed a 3D hydrogel-based microfluidic-device to study the migration behavior of human MSCs in the presence of stromal-cell derived factor-1α (SDF-1α), interleukin 8 (IL-8) and Substance P (SP) which have been utilized as chemoattractant candidates of human mesenchymal stem cells (hMSCs). Results: We systematically investigated the chemotactic migration behaviors of hMSCs and their responses to SDF-1α, IL-8, and SP. SDF-1α was shown to be the most fascinating chemoattractant candidate among those factors at a certain time point. We also found that each chemokine showed different chemoattractant abilities according to their concentration. In the case of SP, this factor showed chemokinesis not chemotaxis. Especially at a 7?8 × 10?8 M concentration range, the chemokinesis ability driven by SP was further increased. The data suggest that some factors at the optimal concentration exhibit chemokinesis or chemotaxis in a 3D hydrogel-based microfluidic device. Conclusion: In this study on chemotaxis and chemokinesis of hMSCs, the system parameters such as chemokine concentration, system stability, and 2D or 3D microenvironment are critically important to obtain meaningful results.
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참고문헌 (29)
참고문헌 신청
Terranova VP / 1985 / Human endothelial cells are chemotactic to endothelial cell growth factor and heparin / J Cell Biol 101:2330~2334
Li L / 2011 / Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms / Front Med 5:33~39
Chen Y / 2010 / Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver / J Cell Mol Med 14:1494~1508
Wang Z / 2015 / Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury / Stem Cells 33:456~467
Sohni A / 2013 / Mesenchymal stem cells migration homing and tracking / Stem Cells Int 2013:130763
Li L / 2011 / Regulatory factors of mesenchymal stem cell migration into injured tissues and their signal transduction mechanisms / Front Med 5:33~39
Chen Y / 2010 / Recruitment of endogenous bone marrow mesenchymal stem cells towards injured liver / J Cell Mol Med 14:1494~1508
Wang Z / 2015 / Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury / Stem Cells 33:456~467
Sohni A / 2013 / Mesenchymal stem cells migration homing and tracking / Stem Cells Int 2013:130763
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