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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 142 - 152 (11page)
- DOI
- 10.1186/s40824-016-0074-2
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초록· 키워드
오류제보하기
Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution imaging technologies have significantly advanced efforts to regenerate in vitro culture or tissue platforms. Relatively simple flat or tubular organs are already in (pre)clinical trials and a few commercial products are in market. The road to more complex, high demand, solid organs including heart, kidney and lung will require substantive technical advancement. Here, we consider two emerging technologies for solid organ fabrication. One is decellularization of cadaveric organs followed by repopulation with terminally differentiated or progenitor cells. The other is 3D bioprinting to deposit cell-laden bio-inks to attain complex tissue architecture. We reviewed the development and evolution of the two technologies and evaluated relative strengths needed to produce solid organs, with special emphasis on the heart and other tissues of the cardiovascular system.
목차
등록된 정보가 없습니다.
참고문헌 (69)
참고문헌 신청
Langer R / 1993 / Tissue engineering / Science 260:920~926
Jung JP / 2012 / Imaging cardiac extracellular matrices : a blueprint for regeneration / Trends Biotech 30:233~240
Hanson KP / 2012 / Spatial and temporal analysis of extracellular matrix proteins in the developing murine heart : a blueprint for regeneration / Tissue Eng Part A 19:1132~1143
Murphy SV / 2014 / 3D bioprinting of tissues and organs / Nat Biotech 32:773~785
O’Brien CM / 2014 / Three-dimensional printing of nanomaterial scaffolds for complex tissue regeneration / Tissue Eng Part B 21:103~114
Jung JP / 2012 / Imaging cardiac extracellular matrices : a blueprint for regeneration / Trends Biotech 30:233~240
Hanson KP / 2012 / Spatial and temporal analysis of extracellular matrix proteins in the developing murine heart : a blueprint for regeneration / Tissue Eng Part A 19:1132~1143
Murphy SV / 2014 / 3D bioprinting of tissues and organs / Nat Biotech 32:773~785
O’Brien CM / 2014 / Three-dimensional printing of nanomaterial scaffolds for complex tissue regeneration / Tissue Eng Part B 21:103~114
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