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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제20권 제6호
- 발행연도
- 2016.11
- 수록면
- 649 - 655 (7page)
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TonEBP belongs to the Rel family of transcription factors and plays important roles in inflammation as well as kidney homeostasis. Recent studies suggest that TonEBP expression is also involved in differentiation of several cell types such as myocytes, chondrocytes, and osteocytes. In this study, we investigated the roles of TonEBP during adipocyte differentiation in 3T3-L1 cells. TonEBP mRNA and protein expression was dramatically reduced during adipocyte differentiation. Sustained expression of TonEBP using an adenovirus suppressed the formation of lipid droplets as well as the expression of FABP4, a marker of differentiated adipocytes. TonEBP also inhibited the expression of PPARγ, a known master regulator of adipocytes. RNAi-mediated knock down of TonEBP promoted adipocyte differentiation. However, overexpression of TonEBP did not affect adipogenesis after the initiation of differentiation. Furthermore, TonEBP expression suppressed mitotic clonal expansion and insulin signaling, which are required early for adipocyte differentiation of 3T3-L1 cells. These results suggest that TonEBP may be an important regulatory factor in the early phase of adipocyte differentiation.
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참고문헌 (31)
참고문헌 신청
Stroud JC / 2002 / Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor / Nat Struct Biol 9:90~94
Halterman JA / 2012 / Tonicity-independent regulation of the osmosensitive transcription factor TonEBP(NFAT5) / Am J Physiol Cell Physiol 302:1~8
Adachi A / 2012 / NFAT5 regulates the canonical Wnt pathway and is required for cardiomyogenic differentiation / Biochem Biophys Res Commun 426:317~323
O'Connor RS / 2007 / A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis / J Cell Sci 120:149~159
Caron MM / 2013 / Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5 / Bone 53:94~102
Halterman JA / 2012 / Tonicity-independent regulation of the osmosensitive transcription factor TonEBP(NFAT5) / Am J Physiol Cell Physiol 302:1~8
Adachi A / 2012 / NFAT5 regulates the canonical Wnt pathway and is required for cardiomyogenic differentiation / Biochem Biophys Res Commun 426:317~323
O'Connor RS / 2007 / A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis / J Cell Sci 120:149~159
Caron MM / 2013 / Osmolarity determines the in vitro chondrogenic differentiation capacity of progenitor cells via nuclear factor of activated T-cells 5 / Bone 53:94~102
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