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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제18권 제4호
- 발행연도
- 2014.8
- 수록면
- 307 - 311 (5page)
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초록· 키워드
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In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effectson melanogenesis. Scopoletin was not toxic to cells at concentrations less than 50 μM and increasedmelanin synthesis in a dose-dependent manner. As melanin synthesis increased, scopoletin stimulatedthe total tyrosinase activity, the rate-limiting enzyme of melanogenesis. In a cell-free system, however,scopoletin did not increase tyrosinase activity, indicating that scopoletin is not a direct activator oftyrosinase. Furthermore, Western blot analysis showed that scopoletin stimulated the production ofmicrophthalmia-associated transcription factor (MITF) and tyrosinase expression via cAMP responseelement-binding protein (CREB) phosphorylation in a dose-dependent manner. Based on these results,preclinical and clinical studies are needed to assess the use of scopoletin for the treatment of vitiligo.
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참고문헌 (22)
참고문헌 신청
Hearing VJ / 1991 / Enzymatic control of pigmentation in mammals / FASEB J 5:2902~2909
조영석 / 2010 / Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1α / The Korean Journal of Physiology & Pharmacology 14(2):91~97
Pichler R / 2006 / Vitiligo patients present lower plasma levels of alpha-melanotropin immunoreactivities / Neuropeptides 40:177~183
WonBinLee / 2002 / Phytochemical Constituens of Cirsium setidens Nakai and Their Cytotoxicity against Human Cancer Cell Lines / Archives of Pharmacal Research 25(5):628~635
Tal B / 1986 / The metabolism of sunflower phytoalexins ayapin and scopoletin: plant-fungus interactions / Plant Physiol 82:167~172
조영석 / 2010 / Pyrithione-zinc Prevents UVB-induced Epidermal Hyperplasia by Inducing HIF-1α / The Korean Journal of Physiology & Pharmacology 14(2):91~97
Pichler R / 2006 / Vitiligo patients present lower plasma levels of alpha-melanotropin immunoreactivities / Neuropeptides 40:177~183
WonBinLee / 2002 / Phytochemical Constituens of Cirsium setidens Nakai and Their Cytotoxicity against Human Cancer Cell Lines / Archives of Pharmacal Research 25(5):628~635
Tal B / 1986 / The metabolism of sunflower phytoalexins ayapin and scopoletin: plant-fungus interactions / Plant Physiol 82:167~172
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