Acetylation Enhances the Promoting Role of AIB1 in Breast Cancer Cell Proliferation

Shan Yan; Dingyun You; Hongbo Zhao; Yan Wang; Yang Jiao; Minnan Lu

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자료유형: 학술저널

저자정보: Shan Yan (Kunming Medical University) Dingyun You (Kunming Medical University) Hongbo Zhao (Kunming Medical University) Yan Wang (Kunming Medical University) Yang Jiao (Kunming Medical University) Minnan Lu (Kunming Medical University)

저널정보: 한국분자세포생물학회 Molecules and Cells Molecules and Cells 제39권 제9호

발행연도: 2016.9

수록면: 663 - 668 (6page)

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The oncogene nuclear receptor coactivator amplified in breast cancer 1 (AIB1) is a transcriptional coactivator, which is overexpressed in various types of human cancers, including breast cancer. However, the molecular mechanisms regulating AIB1 function remain largely unknown. In this study, we present evidence demonstrating that AIB1 is acetylated by MOF in human breast cancer cells. Moreover, we also found that the acetylation of AIB1 enhances its function in promoting breast cancer cell proliferation. We further showed that the acetylation of AIB1 is required for its recruitment to E2F1 target genes by E2F1. More importantly, we found that the acetylation levels of AIB1 are greatly elevated in human breast cancer cells compared with that in non-cancerous cells. Collectively, our results shed light on the molecular mechanisms that regulate AIB1 function in breast cancer.

#acetylation #AIB1 #breast cancer #E2F1 #MOF

참고문헌 (20)

참고문헌 신청

Albertson, D. G / 2006 / Gene amplification in cancer / Trends Genet 22:447~455

Anzick, S. L. / 1997 / AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer / Science 277:965~968

Bautista, S. / 1998 / In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity / Clin. Cancer Res 4:2925~2929

Easton, D. F. / 1993 / Genetic linkage analysis in familial breast and ovarian cancer : results from 214 families. The Breast Cancer Linkage Consortium / Am. J. Hum Genet 52:678~701

Hortobagyi, G. N / 1998 / Treatment of breast cancer / New Engl. J. Med 339:974~984

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