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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.7
- 수록면
- 550 - 556 (7page)
- DOI
- http://dx.doi.org/10.14348/molcells.2016.0069
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초록· 키워드
오류제보하기
During meiosis, exchange of DNA segments occurs be-tween paired homologous chromosomes in order to pro-duce recombinant chromosomes, helping to increase genetic diversity within a species. This genetic exchange process is tightly controlled by the eukaryotic RecA homologs Rad51 and Dmc1, which are involved in strand exchange of meiotic recombination, with Rad51 participating specifically in mitotic recombination. Meiotic recombination requires an interaction between homologous chromosomes to repair programmed double-strand breaks (DSBs). In this study, we investigated the budding yeast meiosis-specific proteins Hop2 and Sae3, which function in the Dmc1-dependent pathway. This pathway mediates the homology searching and strand invasion processes. Mek1 kinase participates in switching meiotic recombination from sister bias to homolog bias after DSB formation. In the absence of Hop2 and Sae3, DSBs were produced normally, but showed defects in the DSB-to-single-end invasion transition mediated by Dmc1 and auxiliary factors, and mutant strains failed to complete proper chromosome segregation. However, in the absence of Mek1 kinase activity, Rad51-dependent recombination progressed via sister bias in the hop2? or sae3? mutants, even in the presence of Dmc1. Thus, Hop2 and Sae3 actively modulate Dmc1-dependent recombination, effectively progressing homolog bias, a process requiring Mek1 kinase activation.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Allers, T. / 2001 / Differential timing and control of noncrossover and crossover recombination during meiosis / Cell 106:47~57
Börner, G. V. / 2004 / Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis / Cell 117:29~45
Busygina, V. / 2008 / Hed1 regulates Rad51-mediated recombination via a novel mechanism / Genes Dev 22:786~795
Cannavo, E. / 2014 / Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks / Nature 514:122~125
Chan, Y. L. / 2014 / The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation / J. Biol. Chem 289:18076~18086
Börner, G. V. / 2004 / Crossover/noncrossover differentiation, synaptonemal complex formation, and regulatory surveillance at the leptotene/zygotene transition of meiosis / Cell 117:29~45
Busygina, V. / 2008 / Hed1 regulates Rad51-mediated recombination via a novel mechanism / Genes Dev 22:786~795
Cannavo, E. / 2014 / Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks / Nature 514:122~125
Chan, Y. L. / 2014 / The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation / J. Biol. Chem 289:18076~18086
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