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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 789 - 795 (7page)
- DOI
- 10.14348/molcells.2015.0109
이용수
초록· 키워드
오류제보하기
A chromosome territory is composed of chromosomal subdomains. The internal structure of chromosomal subdomains provides a structural framework for many genomic activities such as replication and DNA repair, and thus is key to determining the basis of their mechanisms. However, the internal structure and regulating proteins of a chromosomal subdomain remains elusive. Previously, we showed that the chromosome territory expanded after BAF53 knockdown. Because the integrity of chromosomal subdomains is a deciding factor of the volume of a chromosome territory, we examined here the effect of BAF53 knockdown on chromosomal subdomains. We found that BAF53 knockdown led to the disintegration of histone H2B-GFP-visualized chromosomal subdomains and BrdUlabeled replication foci. In addition, the size of DNA loops measured by the maximum fluorescent halo technique increased and became irregular after BAF53 knockdown, indicating DNA loops were released from the residual nuclear structure. These data can be accounted for by the model that BAF53 is prerequisite for maintaining the structural integrity of chromosomal subdomains.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Albiez, H. / 2006 / Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks / Chromosome Res 14:707~733
Andersson, K. / 1980 / The in situ structure of the active 75 S RNA genes in Balbiani rings of Chironomus tentans / Exp. Cell Res 130:313~326
Belmont, A. S. / 1994 / Visualization of G1 chromosomes : a folded, twisted, supercoiled chromonema model of interphase chromatid structure / J. Cell Biol 127:287~302
Buongiorno-Nardelli, M. / 1982 / A relationship between replicon size and supercoiled loop domains in the eukaryotic genome / Nature 298:100~102
Cayrou, C. / 2010 / Programming DNA replication origins and chromosome organization / Chromosome Res 18:137~145
Andersson, K. / 1980 / The in situ structure of the active 75 S RNA genes in Balbiani rings of Chironomus tentans / Exp. Cell Res 130:313~326
Belmont, A. S. / 1994 / Visualization of G1 chromosomes : a folded, twisted, supercoiled chromonema model of interphase chromatid structure / J. Cell Biol 127:287~302
Buongiorno-Nardelli, M. / 1982 / A relationship between replicon size and supercoiled loop domains in the eukaryotic genome / Nature 298:100~102
Cayrou, C. / 2010 / Programming DNA replication origins and chromosome organization / Chromosome Res 18:137~145
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