지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.7
- 수록면
- 624 - 629 (6page)
이용수
초록· 키워드
오류제보하기
Since the emergence of proteomics methods, many proteins specific for renal cell carcinoma (RCC) have been identified.
Despite their usefulness for the specific diagnosis of RCC, such proteins do not provide spatial information on the diseased tissue. Therefore, the identification of cancerspecific proteins that include information on their specific location is needed. Recently, matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS) based imaging mass spectrometry (IMS) has emerged as a new tool for the analysis of spatial distribution as well as identification of either proteins or small molecules in tissues. In this report, surgical tissue sections of papillary RCC were analyzed using MALDI-IMS. Statistical analysis revealed several discriminative cancer-specific m/z-species between normal and diseased tissues. Among these m/z-species, two particular proteins, S100A11 and ferritin light chain, which are specific for papillary RCC cancer regions, were successfully identified using LC-MS/MS following protein extraction from independent RCC samples. The expressions of S100A11 and ferritin light chain were further validated by immunohistochemistry of human tissues and tissue microarrays (TMAs) of RCC. In conclusion, MALDI-IMS followed by LCMS/ MS analysis in human tissue identified that S100A11 and ferritin light chain are differentially expressed proteins in papillary RCC cancer regions.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Andersson, M. / 2008 / Imaging mass spectrometry of proteins and peptides : 3D volume reconstruction / Nat. Methods 5:101~108
Bosso, N. / 2008 / Human urine biomarkers of renal cell carcinoma evaluated by ClinProt / Proteomics Clin. Appl 2:1036~1046
Chaurand, P. / 2002 / Imaging mass spectrometry : a new tool to investigate the spatial organization of peptides and proteins in mammalian tissue sections / Curr. Opin. Chem. Biol 6:676~681
Chaurand, P. / 2005 / Imaging mass spectrometry : principles and potentials / Toxicol. Pathol 33:92~101
Chaurand, P. / 2006 / New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry / J. Proteome Res 5:2889~2900
Bosso, N. / 2008 / Human urine biomarkers of renal cell carcinoma evaluated by ClinProt / Proteomics Clin. Appl 2:1036~1046
Chaurand, P. / 2002 / Imaging mass spectrometry : a new tool to investigate the spatial organization of peptides and proteins in mammalian tissue sections / Curr. Opin. Chem. Biol 6:676~681
Chaurand, P. / 2005 / Imaging mass spectrometry : principles and potentials / Toxicol. Pathol 33:92~101
Chaurand, P. / 2006 / New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry / J. Proteome Res 5:2889~2900
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Recent Advances of MALDI-Mass Spectrometry Imaging in Cancer Research
Mass Spectrometry Letters
2019 .09
-
Effects of drying process and matrix on qualitative analysis of protein using MALDI-MS
한국분석과학회 학술대회
2018 .11
-
Sample Preparation for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry
Mass Spectrometry Letters
2015 .06
-
Analysis of Entamoeba histolytica Membrane via LC-MALDI-TOF/TOF
Mass Spectrometry Letters
2019 .09
-
Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)를 이용한피부 노카르디아증의 진단
대한의진균학회지
2016 .01
-
MALDI-MS analysis of proteins and lipids in bovine milk
한국분석과학회 학술대회
2019 .11
-
Structural analysis of functional materials by MALDI-MS
한국분석과학회 학술대회
2016 .11
-
Reliable Identification of Bacillus cereus Group Species Using Low Mass Biomarkers by MALDI-TOF MS
Journal of Microbiology and Biotechnology
2019 .01
-
Analysis of milk exosomes using MALDI-TOF mass spectrometry
한국분석과학회 학술대회
2020 .11
-
Development of Rapid Antibiotic Susceptibility Test using MALDI-TOF Mass Spectrometry
한국분석과학회 학술대회
2023 .11
-
Enhancement of Peptide Ionization Efficiency through the Addition of Nanoparticles in MALDI Mass Spectrometry
한국분석과학회 학술대회
2024 .11
-
Development of High-throughput Screening Technique for Microbiome Using MALDI-TOF Mass Spectrometry
한국미생물학회 학술대회논문집
2022 .10
-
Quantitative analysis of polymers by MALDI-TOF MS
한국분석과학회 학술대회
2020 .06
-
Mass spectrometry analysis of laser-induced inactivation on bacterial spores by MALDI-TOF-MS
한국분석과학회 학술대회
2020 .06
-
이산화탄소 직접포집(DAC) 및 동시포집전환(RCC) 기술의 우리나라 기술수준 평가 연구: 델파이 방법을 활용한 전문가 설문을 중심으로
한국기후변화학회지
2024 .08
-
Monocarboxylate transporter 9 (MCT9) is down-regulated in renal cell carcinoma
Genes & Genomics
2021 .01
-
MALDI-MS: A Powerful but Underutilized Mass Spectrometric Technique for Exosome Research
Mass Spectrometry Letters
2021 .09
-
Application of MALDI-TOF MS for Gram-negative Bacterial Identification
한국미생물학회 학술대회논문집
2021 .08
-
High-Throughput Screening Technique for Microbiome using MALDI-TOF Mass Spectrometry: A Review
Mass Spectrometry Letters
2022 .12
-
Advances in Ion Mobility Spectrometry-Mass Spectrometry (IMS-MS)-Based Techniques for Elucidating Higher-Order Protein Structures
Mass Spectrometry Letters
2020 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0