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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.7
- 수록면
- 604 - 609 (6page)
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초록· 키워드
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The active metabolite of vitamin D such as 1α,25-dihydroxyvitamin D3 (1 ,25(OH)2D3) is a well-known key regulatory factor in bone metabolism. However, little is known about the potential of vitamin D as an odontogenic inducer in human dental pulp cells (HDPCs) in vitro. The purpose of this study was to evaluate the effect of vitamin D3 metabolite, 1α,25(OH)2D3, on odontoblastic differentiation in HDPCs. HDPCs extracted from maxillary supernumerary incisors and third molars were directly cultured with 1α,25(OH)2D3 in the absence of differentiation-inducing factors. Treatment of HDPCs with 1α,25(OH)2D3 at a concentration of 10 nM or 100 nM significantly upregulated the expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein1 (DMP1), the odontogenesis-related genes. Also, 1α,25(OH)2D3 enhanced the alkaline phosphatase (ALP) activity and mineralization in HDPCs. In addition, 1α,25(OH)2D3 induced activation of extracellular signal-regulated kinases (ERKs), whereas the ERK inhibitor U0126 ameliorated the upregulation of DSPP and DMP1 and reduced the mineralization enhanced by 1α,25(OH)2D3. These results demonstrated that 1α,25(OH)2D3 promoted odontoblastic differentiation of HDPCs via modulating ERK activation.
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참고문헌 (30)
참고문헌 신청
Barron, M. J. / 2008 / Hereditary dentine disorders : dentinogenesis imperfecta and dentine dysplasia / Orphanet. J. Rare. Dis 3:31
Feng, J. Q. / 1998 / Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein(Dspp)gene, which codes for both dentin sialoprotein and dentin phosphorprotein / J. Biol. Chem 273:9457~9464
Ge, C. / 2007 / Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development / J. Cell. Biol 176:709~718
Greenblatt, M. B. / 2010 / The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice / J. Clin. Invest 120:2457~2473
Gronthos, S. / 2000 / Postnatal human dental pulp stem cells(DPSCs)in vitro and in vivo / Proc. Natl. Acad. Sci. USA 97:13625~13630
Feng, J. Q. / 1998 / Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein(Dspp)gene, which codes for both dentin sialoprotein and dentin phosphorprotein / J. Biol. Chem 273:9457~9464
Ge, C. / 2007 / Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal development / J. Cell. Biol 176:709~718
Greenblatt, M. B. / 2010 / The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice / J. Clin. Invest 120:2457~2473
Gronthos, S. / 2000 / Postnatal human dental pulp stem cells(DPSCs)in vitro and in vivo / Proc. Natl. Acad. Sci. USA 97:13625~13630
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