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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.3
- 수록면
- 243 - 249 (7page)
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초록· 키워드
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Ginsenoside, one of the active ingredients of Panax gin-seng, has a variety of physiological and pharmacological actions in various organs. However, little is known about the effects of ginsenosides on gastrointestinal (GI) motility. We studied the modulation of pacemaker potentials by ginsenoside in the interstitial cells of Cajal (ICCs) using the whole-cell patch clamp technique in the current clamp mode. Among ginsenosides, we investigated the effects of ginsenoside Rb1, Rg3 and Rf. While externally applied Rb1 and Rg3 had no effects on pacemaker potentials, Rf caused membrane depolarization. The application of flufenamic acid or niflumic acid abolished the generation of pacemaker potentials and inhibited the Rf-induced membrane depolarization. Membrane depolarization induced by Rf was not inhibited by intracellular application of guanosine 5?-[β-thio]diphosphate trilithium salt. Pre-treatment with a Ca2+-free solution, thapsigargin, a Ca2+-ATPase inhibitor of the endoplasmic reticulum, U-73122, a phospholipase C inhibitor, or 2-APB, an IP3 receptor inhibitor, abolished the generation of pacemaker potentials and suppressed Rf-induced actions. However, treatment with chelerythrine and calphostin C, protein kinase C inhibitors, did not block Rf-induced effects on pacemaker potentials. These results suggest that ginsenoside Rf modulates the pacemaker activities of ICCs and therby regulates intestinal motility.
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참고문헌 (34)
참고문헌 신청
Attele, A. S. / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem. Pharmacol 58:1685~1693
Chen, X / 1996 / Cardiovascular protection by ginsenosides and their nitric oxide releasing action / Clin. Exp. Pharmacol. Physiol 2:728~732
Choi, S. / 2001 / Gαq/11 coupled to mammalian PLCβ3-like enzyme mediates the ginsenoside effect on Ca2+-activated Cl- current in the Xenopus oocytes / J. Biol. Chem 276:48797~48802
Choi, S. / 2001 / A novel activation of Ca2+-activated Cl- channel inXenopus oocytes by Ginseng saponins: evidence for the involvementof phospholipase C and intracellular Ca(2+) mobilization / Br. J. Pharmacol 132:641~648
Furukawa, Y. / 1995 / Effect of Chinese herbal medicine on gastrointestinal motility and bowel obstruction / Jpn. J. Gastroenterol. Surg 28:956~960
Chen, X / 1996 / Cardiovascular protection by ginsenosides and their nitric oxide releasing action / Clin. Exp. Pharmacol. Physiol 2:728~732
Choi, S. / 2001 / Gαq/11 coupled to mammalian PLCβ3-like enzyme mediates the ginsenoside effect on Ca2+-activated Cl- current in the Xenopus oocytes / J. Biol. Chem 276:48797~48802
Choi, S. / 2001 / A novel activation of Ca2+-activated Cl- channel inXenopus oocytes by Ginseng saponins: evidence for the involvementof phospholipase C and intracellular Ca(2+) mobilization / Br. J. Pharmacol 132:641~648
Furukawa, Y. / 1995 / Effect of Chinese herbal medicine on gastrointestinal motility and bowel obstruction / Jpn. J. Gastroenterol. Surg 28:956~960
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