지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.3
- 수록면
- 179 - 187 (9page)
이용수
초록· 키워드
오류제보하기
This study aimed to elucidate the effect of tryptophan (Trp) on gut hormone secretion as well as the roles of the calcium-sensing receptor (CaSR) and its downstream signaling pathway in gut hormone secretion by assessing swine duodenal perfusion in vitro. Swine duodenum was perfused with Krebs-Henseleit buffer as a basal solution. Various concentrations (0, 10, and 20 mM) of Trp were applied to investigate its effect on gut hormone secretion. A CaSR antagonist was used to detect the involvement of CaSR and its signal molecules. The 20 mM Trp concentration promoted the secretion of cholecystokinin (CCK) and glucose-dependent insulinotropic peptide (GIP), elevated the mRNA level of CaSR, and upregulated the protein levels of CaSR, protein kinase C (PKC), and inositol trisphosphate receptor (IP3R). However, NPS 2143, an inhibitor of CaSR, attenuated the CCK and GIP release, reduced the mRNA level of CaSR, and decreased the protein levels of CaSR, PKC, and IP3R with 20 mM Trp perfusion. The results indicate that CCK and GIP secretion can be induced by Trp in swine duodenum in vitro, and the effect is mediated by CaSR and its downstream signal molecules PKC and IP3R.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
De novo a novel variant of CaSR gene in a neonate with congenital hypoparathyroidism
Annals of Pediatirc Endocrinology & Metabolism
2018 .01
-
An Unusual Case of Meningioma Showing Increased CaSR Expression with Parathyroid Carcinoma
Endocrinology and Metabolism
2018 .01
-
Ginsenoside Rg1 attenuates mechanical stress-induced cardiac injury via calcium sensing receptor-related pathway
Journal of Ginseng Research
2021 .11
-
Autosomal dominant hypocalcemia with Bartter syndrome due to a novel activating mutation of calcium sensing receptor, Y829C
Korean journal of pediatrics
2015 .01
-
Calcium Signaling in Salivary Secretion
Journal of Korean Dental Science
2017 .12
-
Biomarkers in Drug Free Subjects with Depression : Correlation with Tryptophan
PSYCHIATRY INVESTIGATION
2019 .01
-
Calcemic response to burns differs between adults and children: A review of the literature
Osteoporosis and Sarcopenia
2017 .01
-
Development and Evaluation of the Korean Version of Hospital-Based Transitional Rehabilitation Program Using Daily Living Home for Spinal Cord Injury
Annals of Rehabilitation Medicine
2021 .10
-
성장호르몬이 단구 세포주 THP-1과 U937의 활성에 미치는 영향 평가
한국보건기초의학회지
2022 .12
-
Nutrient-Based Appetite Regulation
Journal of Obesity & Metabolic Syndrome
2022 .06
-
Incretin Hormones: Pathophysiological Risk Factors and Potential Targets for Type 2 Diabetes
Journal of Obesity & Metabolic Syndrome
2021 .09
-
cAMP Mediated Secretion of Insulin-like Growth Factor-I in the Podocyte
대한의생명과학회지
2025 .03
-
Anti-thrombotic effects of ginsenoside Rk3 by regulating cAMP and PI3K/MAPK pathway on human platelets
Journal of Ginseng Research
2023 .11
-
Expression of TRP calcium channels in human periodontal ligament cells and periodontitis mice
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Participation of Potential Transient Receptors in the Antinociceptive Effect of Pharmacopuncture
Journal of Acupuncture & Meridian Studies
2022 .04
-
The Road towards Triple Agonists: Glucagon-Like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide and Glucagon Receptor - An Update
Endocrinology and Metabolism
2024 .02
-
Involvement of Protein Kinase C-δ in Vascular Permeability in Acute Lung Injury
Immune Network
2015 .08
-
Glucagon-Like Peptide-1 Based Therapies: A New Horizon in Obesity Management
Endocrinology and Metabolism
2024 .04
-
TRPS1 expression in non-melanocytic cutaneous neoplasms: an immunohistochemical analysis of 200 cases
Journal of Pathology and Translational Medicine
2024 .03
-
Compound K ameliorates airway inflammation and mucus secretion through the regulation of PKC signaling in vitro and in vivo
Journal of Ginseng Research
2022 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-528-001366599