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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 189 - 195 (7page)
이용수
이 논문의 연구 히스토리 (2)
2009
Anti-obesity activity of diglyceride containing conjugated linoleic acid in C57BL/6J ob/ob mice
Jin-Joo Hue
,
Ki Nam Lee
,
Jae-Hwang Jeong
외 6명
Journal of Veterinary Science
2009.09
학술저널
Anti-obesity Activity of Diglyceride containing Conjugated Linoleic Acid in C57BL/6J ob/ob Mice
Jin-Joo Hue
,
Jun Hyeong Kim
,
Jong-Soo Kim
외 6명
한국실험동물학회 학술발표대회 논문집
2009.04
학술대회자료
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초록· 키워드
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This study was to investigate the anti-obesity effects of diglyceride (DG)-conjugated linoleic acid (CLA) containing 22% CLA as fatty acids in C57BL/6J ob/ob male mice. There were four experimental groups including vehicle control, DG, CLA, and DG-CLA. The test solutions of 750 mg/kg dose were orally administered to the mice everyday for 5 weeks. CLA treatments significantly decreased mean body weight in the obese mice throughout the experimental period compared to the control (p ＜ 0.01). All test solutions significantly decreased the levels of triglyceride, glucose and free fatty acids in the serum compared with control (p ＜ 0.05). The levels of total cholesterol were also significantly reduced in DG and DG-CLA groups compared with the control group (p ＜ 0.05). CLA significantly decreased weights of renal and epididymal fats compared with the control (p ＜ 0.05). DG and DG- CLA also significantly decreased the epididymal fat weights compared with the control (p ＜ 0.05). A remarkable decrease in the number of lipid droplets and fat globules was observed in the livers of mice treated with DG, CLA, and DG-CLA compared to control. Treatments of DG and CLA actually increased the expression of peroxisome proliferator-activated receptor gamma. These results suggest that DG-CLA containing 22% CLA have a respectable anti-obesity effect by controlling serum lipids and fat metabolism.
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