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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 185 - 190 (6page)
- DOI
- 10.4068/cmj.2021.57.3.185
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초록· 키워드
오류제보하기
Acer mono is known to contain bioactive substances that exhibit beneficial effects in osteoporosis, gastric ulcers, hepatic damage, and pathologic angiogenesis. The current study aimed to investigate the effects of Acer mono extract on the invasive activities and cell-cycle progression of human fibrosarcoma cells. Cytotoxicity of Acer mono extract was assessed by MTT assay, in-vitro invasiveness of HT1080 fibrosarcoma cells was measured using matrigel assay, expression of invasion- and cell-cycle-related proteins was analyzed by western blot analysis, and that of E2F target genes was quantified using qRT-PCR. Acer mono extract did not show distinct cytotoxicity in the experimental concentrations used. Invasiveness of HT1080 fibrosarcoma cells and expression of cyclin D1 and CDK4 in them were significantly reduced in a dose-dependent manner after treatment with Acer mono extract. Acer mono extract showed inhibitory effects on the G1/S transition during cell-cycle progression; the active phosphorylated Rb protein level was decreased, and expression of E2F target genes was downregulated by the Acer mono extract. Our data collectively demonstrated that Acer mono extract exerts inhibitory effects on the invasiveness and cell-cycle progression of HT1080 human fibrosarcoma cells.
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참고문헌 (25)
참고문헌 신청
Lee GS / 2008 / The beneficial effect of the sap of Acer mono in an animal with low-calcium diet-induced osteoporosis-like symptoms / Br J Nutr 100:1011~1018
Seo EJ / 2013 / Antiangiogenic activity and pharmacogenomics of medicinal plants from traditional Korean medicine / Evid Based Complement Alternat Med 2013:131306
Yang H / 2005 / Two new hepatoprotective stilbene glycosides from Acer mono leaves / J Nat Prod 68:101~103
Yang H / 2005 / Protective activities of stilbene glycosides from Acer mono leaves against H2O2-induced oxidative damage in primary cultured rat hepatocytes / J Agric Food Chem 53:4182~4186
Park CH / 2011 / Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration / Exp Ther Med 2:843~848
Seo EJ / 2013 / Antiangiogenic activity and pharmacogenomics of medicinal plants from traditional Korean medicine / Evid Based Complement Alternat Med 2013:131306
Yang H / 2005 / Two new hepatoprotective stilbene glycosides from Acer mono leaves / J Nat Prod 68:101~103
Yang H / 2005 / Protective activities of stilbene glycosides from Acer mono leaves against H2O2-induced oxidative damage in primary cultured rat hepatocytes / J Agric Food Chem 53:4182~4186
Park CH / 2011 / Protective effect of Acer mono Max. sap on water immersion restraint stress-induced gastric ulceration / Exp Ther Med 2:843~848
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