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자료유형
학술저널
저자정보
Noppaket Singkham (Division of Pharmacy Practice Department of Pharmaceutical Care School of Pharmaceutical Sciences U) Yuttana Wongsalap (Division of Pharmacy Practice Department of Pharmaceutical Care School of Pharmaceutical Sciences U) Duangkamon Poolpun (Department of Pharmacy Buddhachinaraj Hospital Phitsanulok Thailand) Sirichok Phetnoo (Division of Pharmacy Practice Department of Pharmaceutical Care School of Pharmaceutical Sciences U) Chuthalak Somkhon (Division of Pharmacy Practice Department of Pharmaceutical Care School of Pharmaceutical Sciences U)
저널정보
대한노인병학회 Annals of geriatric medicine and research Annals of geriatric medicine and research Vol.25 No.4
발행연도
2021.12
수록면
260 - 268 (9page)
DOI
10.4235/agmr.21.0098

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Background Digoxin is used to control heart rate in patients with heart failure (HF) and atrial fibrillation (AF). However, its use is often limited in older patients, as they are prone to digoxin toxicity. This study aimed to determine the prevalence of digoxin use, investigate the factors associated with digoxin use, and explore the association between digoxin use and clinical outcomes in older Thai patients with HF and AF. Methods This cross-sectional study used data obtained from an electronic medical records database. We performed logistic regression analysis to determine the prevalence of digoxin use at index discharge and the factors associated with its use. The Cox proportional hazard model was used to determine the association of all-cause mortality and HF rehospitalization with digoxin use. Results Of the 640 patients assessed, 107 (16.72%) were prescribed digoxin before discharge. The factors negatively associated with digoxin use included high serum creatinine level (adjusted odds ratio [AOR] =0.38; 95% confidence interval [CI], 0.22?0.65) and ischemic heart disease (IHD) (AOR=0.52; 95% CI, 0.30?0.88). The factors positively associated with digoxin use were the use of diuretics (AOR=2.65; 95% CI, 1.60?4.38) and mineralocorticoid receptor antagonists (MRAs) (AOR=2.24; 95% CI, 1.18?4.27). We observed no significant association between digoxin use and clinical outcomes (adjusted hazard ratio=1.00; 95% CI, 0.77?1.30). Conclusion Digoxin use was prevalent among older patients with HF and AF. Patients with high serum creatinine or IHD were less likely to be prescribed digoxin, whereas those using diuretics or MRAs were more likely to be prescribed digoxin. Although digoxin use was not uncommon among older patients, it was prescribed with caution among Thai patients hospitalized with HF and AF.

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