지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 201 - 208 (8page)
- DOI
- 10.17945/kjbt.2021.32.3.201
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초록· 키워드
오류제보하기
Immune-related adverse events, including immune hemolytic anemia, have been reported in patients treated with immune checkpoint inhibitors. In particular, RBC autoantibodies are important because they can cause hemolytic anemia and interfere with pre-transfusion tests. On the other hand, there are few reports on the characteristics of RBC autoantibodies induced by immune checkpoint inhibitors in Korea. The medical history and laboratory results, including pretransfusion tests of ten patients treated with immune checkpoint inhibitors, were reviewed retrospectively. The median interval from the first administration of immune checkpoint inhibitors to the development of autoantibodies was 12 weeks. In eight patients, only cold autoantibodies were developed. Both warm and cold autoantibodies developed in one patient, and warm autoantibodies alone were detected in one patient.
Of seven patients tested by a direct antiglobulin test, two were negative, and the remaining five were positive for IgG and negative for C3d. In conclusion, this study presented ten cases of autoantibody developments in patients treated with immune checkpoint inhibitors and the possible relationship between the immune checkpoint inhibitors and RBC autoantibody development. Further comprehensive studies will be needed to elucidate this relationship.
(Korean J Blood Transfus 2021;32:201-208)
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Seidel JA / 2018 / Anti-PD-1and Anti-CTLA-4 therapies in cancer : mechanisms of action, efficacy, and limitations / Front Oncol 8:86
Haanen JB / 2015 / Immune checkpoint inhibitors / Prog Tumor Res 42:55~66
Vinay DS / 2015 / Immune evasion in cancer: mechanistic basis and therapeutic strategies / Semin Cancer Biol. 35:S185~S198
Michot JM / 2016 / Immunerelated adverse events with immune checkpoint blockade : a comprehensive review / Eur J Cancer 54:139~148
Ramos-Casals M / 2020 / Immune-related adverse events of checkpoint inhibitors / Nat Rev Dis Primers 6:38
Haanen JB / 2015 / Immune checkpoint inhibitors / Prog Tumor Res 42:55~66
Vinay DS / 2015 / Immune evasion in cancer: mechanistic basis and therapeutic strategies / Semin Cancer Biol. 35:S185~S198
Michot JM / 2016 / Immunerelated adverse events with immune checkpoint blockade : a comprehensive review / Eur J Cancer 54:139~148
Ramos-Casals M / 2020 / Immune-related adverse events of checkpoint inhibitors / Nat Rev Dis Primers 6:38
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