메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Jeongwoen Shin (Chungnam National University) Dong Jae Lee (Chungnam National University) Dongwon Seo (Chungnam National University) SooHyun Lee (National Institute of Animal Science) You-Sam Kim (TNT Research. Co. Ltd) 박명흠 (TNT Research. Co. Ltd) Cedric Gondro (Michigan State University) Yang-Mo Koo (Korea Animal Improvement Association) Seung Hwan Lee (Chungnam National University)
저널정보
한국동물유전육종학회 Journal of Animal Breeding and Genomics Journal of Animal Breeding and Genomics Vol.5 No.4
발행연도
2021.12
수록면
255 - 266 (12page)
DOI
10.12972/jabng.20210026

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
With rapid advances in next-generation sequencing technology, previously released reference genomes are being upgraded, and new genome assemblies for novel organisms are being published. In recent updates of the bovine reference genome, changes in single-nucleotide polymorphism (SNP) position and gene location occurred. The BovineSNP50 BeadChip series and Hanwoo SNP50K BeadChip are based on the older version of the bovine reference assembly UMD3.1. In a recent bovine reference genome of ARS-UCD1.2, SNP positions changed in the map file of a commercial SNP chip. Hence, this study assessed SNP re-positioning in the updated reference genome using the LiftoverVcf tool. We annotated SNP variants, which were mapped to both reference genomes, to compare SNP information such as position and adjacent genes between assemblies. The results showed that approximately 3.5~4.0% of the SNPs failed the lift-over procedure. Moreover, the number of SNPs successfully lifted over that affect protein expression, number of effects according to SNP type, and locations of Hanwoo economic trait-related candidate genes differed between reference genomes. In conclusion, the map file of SNP chip data based on UMD3.1 needs to use the position information of ARS-UCD1.2, a new reference genome, for accurate comparison with other currently published studies.

목차

등록된 정보가 없습니다.

참고문헌 (18)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0