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Development of Subretinal Hemorrhage during Treatment of Neovascular Age-related Macular Degeneration Using a Treat-and-extend Regimen: A Case Report
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습성 나이관련황반변성에 대한 treat-and-extend 치료 중 발생한 망막하출혈: 증례보고

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Type
Academic journal
Author
Jae Hui Kim (김안과병원)
Journal
한국망막학회 Journal of Retina Journal of Retina Vol.6 No.2 KCI Accredited Journals
Published
2021.11
Pages
155 - 161 (7page)

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Development of Subretinal Hemorrhage during Treatment of Neovascular Age-related Macular Degeneration Using a Treat-and-extend Regimen: A Case Report
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Purpose: To report a case of subretinal hemorrhage that developed during treatment of neovascular age-related macular degeneration (nAMD) using a treat-and-extend (TAE) regimen. Case summary: A 69-year-old woman was diagnosed with nAMD. Three monthly ranibizumab injections were performed as an initial treatment. Then, treatment was performed as-needed for 32 months. At 32 months, the treatment regimen was switched to TAE, which is characterized by continuous injections with 1 to 3 months interval regardless of recurrence. During the 31-month TAE period, 14 anti- vascular endothelial growth factor injections were performed. At 31 months, the injection interval was 2 months, and no subretinal or intraretinal fluid was observed on optical coherence tomography. Best-corrected visual acuity (BCVA) was 0.2. At 33 months, subretinal hemorrhage developed with deterioration of BCVA to 0.04. Three ranibizumab injections were performed, but subretinal hemorrhage did not resolve. Conclusions: Extensive subretinal hemorrhage can develop even in patients treated with TAE regimen. Further studies are required to more effectively prevent the hemorrhage.
#Age related macular degeneration #Choroidal neovascularization #Retinal hemorrhage

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References (25)

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Bressler SB / 1982 / Natural course of choroidal neovascular membranes within the foveal avascular zone in senile macular degeneration / Am J Ophthalmol 93:157~163 google schola Rosenfeld PJ / 2006 / Ranibizumab for neovascular age-related macular degeneration / N Engl J Med 355:1419~1431 google schola Schmidt-Erfurth U / 2014 / Intravitreal aflibercept injection for neovascular age-related macular degeneration : ninety-six-week results of the VIEW studies / Ophthalmology 121:193~201 google schola Writing Committee for the UK Age-Related Macular Degeneration EMR Users Group / 2014 / The neovascular age-related macular degeneration database: multicenter study of 92 976 ranibizumab injections: report 1: visual acuity / Ophthalmology 121:1092~1101 google schola Holz FG / 2015 / Multi-country real-life experience of anti-vascular endothelial growth factor therapy for wet age-related macular degeneration / Br J Ophthalmol 99:220~226 google schola

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