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논문 기본 정보

자료유형
학술저널
저자정보
Masahiro Tada (Department of Orthopaedic Surgery Osaka City General Hospital Osaka Japan) Yutaro Yamada (Department of Orthopaedic Surgery Osaka City University Medical School Osaka Japan) Koji Mandai (Department of Orthopaedic Surgery Osaka Saiseikai Nakatsu Hospital Osaka Japan) Yoshinari Matsumoto (Department of Medical Nutrition Osaka City University Graduate School of Human Life Science Japan) Noriaki Hidaka (Department of Orthopaedic Surgery Osaka City General Hospital Osaka Japan)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.7 No.4
발행연도
2021.12
수록면
140 - 145 (6page)
DOI
10.1016/j.afos.2021.11.002

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Objectives: Osteosarcopenia is defined as osteoporosis with sarcopenia. The impacts of osteosarcopenia on falls and fractures in rheumatoid arthritis (RA) patients were investigated using 4 years of data from a longitudinal study (CHIKARA study). Methods: The patients were divided into 4 groups by their baseline status: no sarcopenia and no osteoporosis (SP-OP-); only sarcopenia (SP + OP-); only osteoporosis (SP-OP+); and both sarcopenia and osteoporosis (SP + OP+). Survival rates and Cox hazard ratios were analyzed using falls and fractures as endpoints, adjusted by age, sex, and body mass index. Results: A total of 100 RA patients (SP-OP-: 44%, SP + OP-: 17%, SP-OP+: 28%, and SP + OP+: 11%) were enrolled; 37 patients had falls, and 19 patients had fractures. The fall-free and fracture-free survival rates were significantly lower in SP + OP+ (36.4%, 54.5%) than in SP-OP- (75.0%, 86.4%). The hazard ratio of falls was significantly increased in SP + OP+, by 3.32-fold (95%CI: 1.01-10.9), whereas in SP + OP- and SP-OP+, there were no differences compared to SP-OP-. Conclusions: The survival rates with the endpoints of falls and fractures in RA patients with osteosarcopenia were lower during 4-year follow-up. The risk of falls increased with the synergistic effect of osteoporosis and sarcopenia.

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