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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.10 No.3
- 발행연도
- 2021.9
- 수록면
- 259 - 263 (5page)
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초록· 키워드
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Adjuvants are often required to improve the potentially low immunogenicity of vaccines. In this study, it is proposed to use an emulsion based on fluorocarbons as an adjuvant. Since this emulsion adsorbs only a small range of proteins, apolipoprotein A-I (ApoAI) was used as an anchor. Antigen and ApoAI were combined by creating a fusion construct. Results showed that the combined use of a perfluorocarbon emulsion and ApoAI during immunization significantly increases the specific antibody titer in mice and in its effectiveness this system is close to the incomplete Freund’s adjuvant.
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참고문헌 (12)
참고문헌 신청
Subiza JL / 2015 / New developments in oral vaccines and mucosal adjuvants / Recent Pat Inflamm Allergy Drug Discov 9:4~15
Laupeze B / 2019 / Adjuvant systems for vaccines : 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood / Vaccine 37:5670~5680
Maevsky EI / 2003 / Emulsion of perfluoroorganic compounds for medical purposes, a process for the preparation thereof and methods for treating and preventing diseases with the use thereof: United States Patent US6,562,872B1 / United States Patent and Trademark Office
Spiess BD / 2019 / Perfluorocarbon emulsions, platelet counts, and inflammation / Shock 52(1S Suppl 1):13~18
Sklifas AN / 2012 / Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268(in vitro and in vivo studies) / Biophysics 57:222~228
Laupeze B / 2019 / Adjuvant systems for vaccines : 13 years of post-licensure experience in diverse populations have progressed the way adjuvanted vaccine safety is investigated and understood / Vaccine 37:5670~5680
Maevsky EI / 2003 / Emulsion of perfluoroorganic compounds for medical purposes, a process for the preparation thereof and methods for treating and preventing diseases with the use thereof: United States Patent US6,562,872B1 / United States Patent and Trademark Office
Spiess BD / 2019 / Perfluorocarbon emulsions, platelet counts, and inflammation / Shock 52(1S Suppl 1):13~18
Sklifas AN / 2012 / Blood plasma protein adsorption capacity of perfluorocarbon emulsion stabilized by proxanol 268(in vitro and in vivo studies) / Biophysics 57:222~228
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