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논문 기본 정보

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학술저널
저자정보
Yagi Kiyoshi (Nagoya City University Graduate School of Medical Sciences) Goto Yuta (Nagoya City University Graduate School of Medical Sciences) Kato Kenji (Nagoya City University Graduate School of Medical Sciences) Suzuki Nobuyuki (Nagoya City University Graduate School of Medical Sciences) Kondo Akira (Nagoya City University Graduate School of Medical Sciences) Waseda Yuya (Nagoya City University Graduate School of Medical Sciences) Mizutani Jun (Nagoya City University Graduate School of Medical Sciences) Kawaguchi Yohei (Nagoya City University Graduate School of Medical Sciences) Joyo Yuji (Nagoya City University Graduate School of Medical Sciences) Waguri-Nagaya Yuko (Nagoya City East Medical Center Nagoya Japan) Murakami Hideki (Nagoya City University Graduate School of Medical Sciences)
저널정보
대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.15 No.6
발행연도
2021.12
수록면
713 - 720 (8page)
DOI
10.31616/asj.2020.0425

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Study Design Human ligamentum flavum?derived cells (HFCs) were obtained from surgical samples for a basic experimental study. Purpose We sought to evaluate the inflammatory response of human ligamentum flavum cells to investigate hypertrophic changes occurring in the ligamentum flavum. Overview of Literature Lumbar spinal stenosis (LSS) is a disease commonly observed in the elderly. The number of patients with LSS has increased over time, yet the pathomechanisms of LSS still have not been fully elucidated. One of the clinical features of LSS is hypertrophy of the ligamentum flavum, which results in narrowing of the lumbar spinal canal. Some reports have suggested that ligamentum flavum hypertrophy is associated with inflammation and fibrosis; meanwhile, the p38 mitogen-activated protein (MAP) kinase is involved in the hypertrophy of human ligamentum flavum cells. Methods HFCs were obtained from patients with LSS who underwent surgery. HFCs were stimulated by tumor necrosis factor-α (TNF-α) and a p38 MAP kinase inhibitor, SB203580. Phosphorylation of the p38 MAP kinase was analyzed by western blotting. The concentration of interleukin-6 (IL-6) in the conditioned medium was measured by enzyme-linked immunoassay and IL-6 messenger RNA expression levels were determined by real-time polymerase chain reaction. Results TNF-α induced the phosphorylation of p38 MAP kinase in a time-dependent manner, which was suppressed by the p38 MAP kinase inhibitor, SB203580. TNF-α also stimulated IL-6 release in both a time- and dose-dependent manner. On its own, SB203580 did not stimulate IL-6 secretion from HFCs; however, it dramatically suppressed the degree of IL-6 release stimulated by TNF-α from HFCs. Conclusions This is the first report suggesting that TNF-α stimulates the gene expression and protein secretion of IL-6 via p38 MAP kinase in HFCs. A noted association between tissue hypertrophy and inflammation suggests that the p38 MAP kinase inflammatory pathway may be a therapeutic molecular target for LSS.
#Spinal stenosis #Ligamentum flavum #p38 mitogen-activated protein kinases #Tumor necrosis factor-alpha #Interleukin-6

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참고문헌 (30)

참고문헌 신청
Jensen RK / 2020 / Prevalence of lumbar spinal stenosis in general and clinical populations : a systematic review and meta-analysis / Eur Spine J 29:2143~2163 google schola Kreiner DS / 2013 / An evidence-based clinical guideline for the diagnosis and treatment of degenerative lumbar spinal stenosis(update) / Spine J 13:734~743 google schola Tomkins-Lane CC / 2010 / Validity and reproducibility of self-report measures of walking capacity in lumbar spinal stenosis / Spine(Phila Pa 1976) 35:2097~2102 google schola Cook CJ / 2020 / Systematic review of diagnostic accuracy of patient history, clinical findings, and physical tests in the diagnosis of lumbar spinal stenosis / Eur Spine J 29:93~112 google schola Otani K / 2013 / Lumbar spinal stenosis has a negative impact on quality of life compared with other comorbidities : an epidemiological cross-sectional study of 1862 communitydwelling individuals / ScientificWorldJournal 2013:590652 google schola

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