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논문 기본 정보

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학술저널
저자정보
Tsuji Osahiio (Orthopaedic Surgery Keio University School of Medicine Tokyo Japan) Kosugi Shizuko (Anesthesiology Keio University School of Medicine Tokyo Japan) Suzuki Satoshi (Keio University School of Medicine Tokyo Japan) Nori Satoshi (Keio University School of Medicine Tokyo Japan) Nagoshi Narihito (Keio University School of Medicine Tokyo Japan) Okada Eijiro (Keio University School of Medicine Tokyo Japan) Fujita Nobuyuki (Fujita Health University Toyoake Japan) Yagi Mitsuru (Keio University School of Medicine Tokyo Japan) Nakamura Masaya (Keio University School of Medicine Tokyo Japan) Matsumoto Morio (Keio University School of Medicine Tokyo Japan) Watanabe Kota (Keio University School of Medicine Tokyo Japan)
저널정보
대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.15 No.5
발행연도
2021.10
수록면
650 - 658 (9page)
DOI
10.31616/asj.2020.0191

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Study Design: This is a retrospective observational study with an outpatient setting. Purpose: This study aimed to describe the effects of duloxetine (DLX) administration for postsurgical chronic neuropathic disorders (both pain and numbness) following spinal surgery in patients without depression. Overview of Literature: Although several reports indicated the potential of DLX to effectively treat postoperative symptoms as a perioperative intervention, there have been no reports of its positive effect on postsurgical chronic neuropathic disorders. Methods: A total of 24 patients with postsurgical chronic pain and/or numbness Numeric Rating Scale (NRS) scores of ≥4 were enrolled. All patients underwent spine or spinal cord surgery at Keio University Hospital and received daily administration of DLX for more than 3 months. The mean postoperative period before the first administration of DLX was 35.5±57.0 months. DLX was administered for more than 3 months at a dose of 20, 40, or 60 mg/day, and the degree of pain and numbness was evaluated using the NRS before administration and 3 months after administration. Effectiveness was defined as more than a 2-point decrease in the NRS score following administration. Results: In terms of the type of symptoms, 15 patients experienced only numbness, eight experienced both pain and numbness, and one experienced only pain. Of the 24 patients, 19 achieved effective relief with DLX. DLX was effective for all patients with postsurgical chronic pain (n=9), and it reduced postsurgical chronic numbness in 18 of 23 patients. No significant difference was observed in background spinal disorders. DLX was not effective for five patients who complained only of postsurgical chronic numbness. Conclusions: This study reports the effectiveness of DLX for postsurgical chronic neuropathic disorders. Although DLX reduced postsurgical chronic pain (efficacy rate=100%) and numbness (78.3%) in certain patients, further investigation is needed to determine its optimal use.
#Duloxetine hydrochloride #Chronic pain #Numbness #Postsurgical neuropathic disorders

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참고문헌 (30)

참고문헌 신청
조재환 / 2017 / Neuropathic Pain after Spinal Surgery / Asian Spine Journal 11(4):642~652 dbpia Haanpaa M / 2011 / NeuPSIG guidelines on neuropathic pain assessment / Pain 152:14~27 google schola Khosravi MB / 2014 / Gabapentin versus naproxen in the management of failed back surgery syndrome; a randomized controlled trial / Acta Anaesthesiol Belg 65:31~37 google schola Baber Z / 2016 / Failed back surgery syndrome : current perspectives / J Pain Res 9:979~987 google schola Wernicke JF / 2006 / A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain / Neurology 67:1411~1420 google schola

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