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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 127 - 134 (8page)
- DOI
- 10.11106/ijt.2021.14.2.127
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초록· 키워드
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Background and Objectives: Even though most of the thyroid cancer shows good prognosis, de-differentiatedthyroid cancer is still refractory to conventional treatments. Recently, kinase inhibitors including multi-kinase andBRAF inhibitors are widely used for treatment of de-differentiated thyroid cancers, but resistant to single kinaseinhibitor treatment eventually encountered. Therefore, combination therapy may have better therapeutic effectthan single therapy for thyroid cancer. In this study, we evaluated therapeutic effect of multi-kinase and BRAFinhibitor combination to anaplastic thyroid cancer cell lines with and without BRAF mutation. Materials andMethods: We used anaplastic thyroid cancer cell lines with BRAFV600E mutation (8505C) and with NRAS mutation(HTh7). Both cell lines were treated with various concentration of multi-kinase inhibitor (lenvatinib) and BRAFinhibitor (vemurafenib). And combination of various concentration of both kinase inhibitors were used to treatboth cell lines. Cytotoxic effect was assessed with cell counting kit-8 and therapeutic effect of single kinaseinhibitor therapy and the combination therapy was compared. Results: Anti-proliferative effect of vemurafenibon 8505C BRAFV600E-mutated cells was demonstrated from 0.25 μM concentration. However, HTh7 cells withNRAS mutation represented drug resistance up to 4 μM of vemurafenib. In case of lenvatinib treatment as amulti-kinase inhibitor, 8505C and HTh7 cells showed decreased cell viability dose-dependent manner. Combinationtreatment with vemurafenib and lenvatinib showed synergistic cytotoxic effect in BRAF mutated 8505C cell line,even at lower concentrations. Conclusion: Combination treatment with multi-kinase inhibitor and BRAF inhibitorshowed promising therapeutic results in BRAF mutated anaplastic thyroid cancer cell line.
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참고문헌 (17)
참고문헌 신청
Fagin JA / 2016 / Biologic and clinical perspectives on thyroid cancer / N Engl J Med 375(11):1054~1067
Nagaiah G / 2011 / Anaplastic thyroid cancer : a review of epidemiology, pathogenesis, and treatment / J Oncol 2011:542358
Smallridge RC / 2009 / Anaplastic thyroid cancer : molecular pathogenesis and emerging therapies / Endocr Relat Cancer 16(1):17~44
Landa I / 2016 / Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers / J Clin Invest 126(3):1052~1066
Lee JH / 2007 / Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid : a meta-analysis / Cancer 110(1):38~46
Nagaiah G / 2011 / Anaplastic thyroid cancer : a review of epidemiology, pathogenesis, and treatment / J Oncol 2011:542358
Smallridge RC / 2009 / Anaplastic thyroid cancer : molecular pathogenesis and emerging therapies / Endocr Relat Cancer 16(1):17~44
Landa I / 2016 / Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers / J Clin Invest 126(3):1052~1066
Lee JH / 2007 / Clinicopathologic significance of BRAF V600E mutation in papillary carcinomas of the thyroid : a meta-analysis / Cancer 110(1):38~46
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