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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 215 - 224 (0page)
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Spirulina (Arthrospira platensis) is a blue-green microalga with bioactive molecules. Blue spirulina is a phycocyanin extracted from spirulina. We investigated the protective effects of spirulina (SP) and blue spirulina (BS) on a dextran sulfate sodium (DSS)-induced colitis mice. SP or BS was administered orally at 100 and 400 mg/kg/day, respectively for 12 days, and colitis was induced by oral gavage with 2.5% DSS for 5 days on the 8th day. DSS-induced colitis mice showed severe bloody stools, diarrhea, weight loss, and colon shortening. However, SP and BS treatments improved the disease activity index (DAI) score and colon length. The improvement of colitis symptoms was validated by reduced levels of proinflammatory cytokines such as TNF-α, IL-6, and IL-1β. Moreover, SP and BS significantly reduced colonic myeloperoxidase and prostaglandin E2 activities in DSS-induced colitis. These results suggest that SP and BS have protective potential against DSS-induced colitis by suppressing excessive inflammatory response.
The findings of this study suggest that SP and BS have substantial potential for the treatment of inflammatory colitis.
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