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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 205 - 214 (10page)
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Herbal preparations are combinations of botanical extracts that are assumed to exert additive and synergistic effects. In this study, we investigated the effects of individual ethanol extracts of Wolfiporia extensa (TD1), Atractylodes japonica (TD2), Paeonia lactiflora (TD3), and mixtures thereof (TD4?TD7) on improvements in hepatic function and hepatocyte protection in human hepatocyte carcinoma (HepG2) cells. Prior to this experiment, we determined the appropriate dose for the treatment using TD1, TD2, TD3, and TD4?TD7 on the viability of HepG2 cells. Results showed that these extracts ameliorated cell toxicity against acetaminophen (APAP)-induced cell death in human hepatocyte carcinoma cells. Additionally, they significantly reduced lactate dehydrogenase (LDH) levels. We also evaluated the effect of TD1?TD7 on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. We found that treatment with TD1?TD7 slightly attenuated the increase in AST and ALT levels compared to APAP-treated HepG2 cells. These results indicate that Wolfiporia extensa, Atractylodes japonica, and Paeonia lactiflora extracts and their mixtures could help improve hepatic function and induce hepatocyte protection.
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