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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 120 - 127 (8page)
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초록· 키워드
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Background: We evaluated three commercially available vitamin D assays to evaluate and compare the correlation and accuracy among them.
Methods: Vitamin D was measured in 71 patient samples using the Architect 25-OH vitamin D assay (Abbott), the ADVIA Centaur vitamin D total assay (Siemens), and the LIAISON 25 OH vitamin D total assay (Diasorin). The evaluation made use of both patient samples and standard reference material, SRM 972. To analyze correlations and differences, Pearson’s correlation coefficients and paired sample t-tests were performed.
Results: Correlations among the three evaluated assays showed strong positive linear relationships (correlations among Siemens and DiaSorin, DiaSorin and Abbott, Abbott and Siemens: r=0.935, r=0.927, r=0.909, respectively). Mean (SD) vitamin D values on Siemens, Abbott, and DiaSorin assays in the 71 patient samples were 23.09 (10.41), 16.75 (11.26), and 16.76 (9.32), respectively. Results for the Siemens assay were significantly different from the other two methods (P<0.001). Target values for SRM 972 level 1, 2, 3, and 4 were 23.9, 14.0, 44.9, and 35.4, respectively. The Abbott, Siemens, and Diasorin assay values were closest to the target values in level 1, levels 2 and 3, and level 4, respectively.
Conclusions: Correlations among vitamin D assays were good; however, the mean values of the Siemens assay were significantly higher than those of DiaSorin or Abbott. We found significant differences in vitamin D levels and discrepancies between patient samples and SRM 972 samples, which should be considered during use in a clinical setting.
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참고문헌 (37)
참고문헌 신청
Audran M / 1985 / The physiology and pathophysiology of vitamin D / Mayo Clin Proc 60:851~866
Chlebowski RT / 2011 / Vitamin D and breast cancer : interpreting current evidence / Breast Cancer Res 13:217
Chiang KC / 2011 / Hepatocellular carcinoma and vitamin D : a review / J Gastroenterol Hepatol 26:1597~1603
Woloszynska-Read A / 2011 / Vitamin D and cancer : clinical aspects / Best Pract Res Clin Endocrinol Metab 25:605~615
Choi HS / 2011 / Low serum vitamin D is associated with high risk of diabetes in Korean adults / J Nutr 141:1524~1528
Chlebowski RT / 2011 / Vitamin D and breast cancer : interpreting current evidence / Breast Cancer Res 13:217
Chiang KC / 2011 / Hepatocellular carcinoma and vitamin D : a review / J Gastroenterol Hepatol 26:1597~1603
Woloszynska-Read A / 2011 / Vitamin D and cancer : clinical aspects / Best Pract Res Clin Endocrinol Metab 25:605~615
Choi HS / 2011 / Low serum vitamin D is associated with high risk of diabetes in Korean adults / J Nutr 141:1524~1528
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